ArticleMolecular pain2011
Ensemble encoding of nociceptive stimulus intensity in the rat medial and lateral pain systems.
Article in Molecular pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 57 citations in OpenAlex.
- Intensity-dependent topographical expansion of sensory representations.bioRxiv : the preprint server for biology · 2026Article
- Deciphering Authentic Nociceptive Thalamic Responses in Rats.Research (Washington, D.C.) · 2024Article
- Interhemispheric neural characteristics of noxious mechano-nociceptive stimulation in the anterior cingulate cortex.Frontiers in neural circuits · 2023Article
- Neuroinflammation in the anterior cingulate cortex: the potential supraspinal mechanism underlying the mirror-image pain following motor fiber injury.Journal of neuroinflammation · 2022Article
- Synaptamide Improves Cognitive Functions and Neuronal Plasticity in Neuropathic Pain.International journal of molecular sciences · 2021Article
- Mapping Cortical Integration of Sensory and Affective Pain Pathways.Current biology : CB · 2020Article
- Modeling the daily rhythm of human pain processing in the dorsal horn.PLoS computational biology · 2019Article
- Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain.Journal of neuroinflammation · 2019Article
- Emotional Mirror Neurons in the Rat's Anterior Cingulate Cortex.Current biology : CB · 2019Article
- Distributions of different types of nociceptive neurons in thalamic mediodorsal nuclei of anesthetized rats.The journal of physiological sciences : JPS · 2019Article
- Ensembles of change-point detectors: implications for real-time BMI applications.Journal of computational neuroscience · 2019Article
- Ketamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex.Nature communications · 2018Article
- Rate and Temporal Coding Mechanisms in the Anterior Cingulate Cortex for Pain Anticipation.Scientific reports · 2018Article
- Scaling Up Cortical Control Inhibits Pain.Cell reports · 2018Article
- Real-time particle filtering and smoothing algorithms for detecting abrupt changes in neural ensemble spike activity.Journal of neurophysiology · 2018Article
- Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex.Frontiers in cellular neuroscience · 2018Article
- Persistent Valence Representations by Ensembles of Anterior Cingulate Cortex Neurons.Frontiers in systems neuroscience · 2018Article
- Deciphering neuronal population codes for acute thermal pain.Journal of neural engineering · 2017Article
- Article
- A Plea for Cross-species Social Neuroscience.Current topics in behavioral neurosciences · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
backgroundThe ability to encode noxious stimulus intensity is essential for the neural processing of pain perception. It is well accepted that the intensity information is transmitted within both sensory and affective pathways. However, it remains unclear what the encoding patterns are in the thalamocortical brain regions, and whether the dual pain systems share similar responsibility in intensity coding.
resultsMultichannel single-unit recordings were used to investigate the activity of individual neurons and neuronal ensembles in the rat brain following the application of noxious laser stimuli of increasing intensity to the hindpaw. Four brain regions were monitored, including two within the lateral sensory pain pathway, namely, the ventral posterior lateral thalamic nuclei and the primary somatosensory cortex, and two in the medial pathway, namely, the medial dorsal thalamic nuclei and the anterior cingulate cortex. Neuron number, firing rate, and ensemble spike count codings were examined in this study. Our results showed that the noxious laser stimulation evoked double-peak responses in all recorded brain regions. Significant correlations were found between the laser intensity and the number of responsive neurons, the firing rates, as well as the mass spike counts (MSCs). MSC coding was generally more efficient than the other two methods. Moreover, the coding capacities of neurons in the two pathways were comparable.
conclusionThis study demonstrated the collective contribution of medial and lateral pathway neurons to the noxious intensity coding. Additionally, we provide evidence that ensemble spike count may be the most reliable method for coding pain intensity in the brain.
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