Evidence map›Paper›PMID 21864354›Full record

ReviewJournal of biomedical science2011

Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.

Gang Wu, Xupei Huang, Yimin Hua, Dezhi Mu

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of biomedical science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. AFrontiers in pediatrics · 2019
    Article
  6. Article
  7. Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Article
  8. Article
  9. Exome analysis in an Estonian multiplex family with neural tube defects-a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017
    Article
  10. Article
  11. Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Apico-basal polarity complex and cancer.Journal of biosciences · 2014
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Gang WuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Xupei Huang
Yimin Hua
Dezhi Mu
West China Second University Hospital of Sichuan University · CNFlorida Atlantic University · USSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural tube defects (NTDs) are the second most common birth defect in humans. Despite many advances in the understanding of NTDs and the identification of many genes related to NTDs, the fundamental etiology for the majority of cases of NTDs remains unclear. Planar cell polarity (PCP) signaling pathway, which is important for polarized cell movement (such as cell migration) and organ morphogenesis through the activation of cytoskeletal pathways, has been shown to play multiple roles during neural tube closure. The disrupted function of PCP pathway is connected with some NTDs. Here, we summarize our current understanding of how PCP factors affect the pathogenesis of NTDs.

Indexed as

Adaptor Proteins, Signal TransducingCadherinsCarrier ProteinsCell PolarityCytoskeletal ProteinsDishevelled ProteinsFrizzled ReceptorsHumansLIM Domain ProteinsMembrane ProteinsNeural Tube DefectsPhosphoproteinsSignal TransductionSpecies SpecificityTumor Suppressor ProteinsWnt ProteinsAdaptor Proteins, Signal TransducingANKRD6 protein, humanCadherinsCarrier ProteinsCELSR1 cadherin, humanCytoskeletal ProteinsDishevelled ProteinsFrizzled ReceptorsLIM Domain ProteinsMembrane ProteinsPhosphoproteinsPRICKLE1 protein, humanTumor Suppressor ProteinsVANGL1 protein, humanWnt Proteins

Identifiers

PMID21864354
PMCPMC3175158
OpenAlexW2111098039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.