ArticleBiomacromolecules2011
Directed intermixing in multicomponent self-assembling biomaterials.
Article in Biomacromolecules, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Active immunotherapy for C5a-mediated inflammation using adjuvant-free self-assembled peptide nanofibers.Acta biomaterialia · 2024Article
- Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups.ACS applied bio materials · 2023Review
- A sublingual nanofiber vaccine to prevent urinary tract infections.Science advances · 2022Article
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Article
- Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide AdjuvanticityACS biomaterials science & engineering · 2021Article
- Modular complement assemblies for mitigating inflammatory conditions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Versatile Manipulations of Self-Assembled Proteins in Vaccine Design.International journal of molecular sciences · 2021Review
- Design of RGDS Peptide-Immobilized Self-Assembling β-Strand Peptide from Barnacle Protein.International journal of molecular sciences · 2021Article
- Enabling sublingual peptide immunization with molecular self-assemblies.Biomaterials · 2020Article
- Low Molecular Weight Supramolecular Hydrogels for Sustained and LocalizedACS applied bio materials · 2019Article
- A genetically engineered Fc-binding amphiphilic polypeptide for congregating antibodies in vivo.Acta biomaterialia · 2019Article
- Toward reducing biomaterial antigenic potential: a miniaturized Fc-binding domain for local deposition of antibodies.Biomaterials science · 2019Article
- Multicomponent peptide assemblies.Chemical Society reviews · 2018Review
- Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers.Biomaterials · 2017Article
- Article
- Creating biomaterials with spatially organized functionality.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Thermal stability of self-assembled peptide vaccine materials.Acta biomaterialia · 2016Article
- Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.Cellular and molecular bioengineering · 2015Article
- Epitope topography controls bioactivity in supramolecular nanofibers.Biomaterials science · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The noncovalent coassembly of multiple different peptides can be a useful route for producing multifunctional biomaterials. However, to date, such materials have almost exclusively been investigated as homogeneous self-assemblies, having functional components uniformly distributed throughout their supramolecular structures. Here we illustrate control over the intermixing of multiple different self-assembling peptides, in turn providing a simple but powerful means for modulating these materials' mechanical and biological properties. In β-sheet fibrillizing hydrogels, significant increases in stiffening could be achieved using heterobifunctional cross-linkers by sequestering peptides bearing different reactive groups into distinct populations of fibrils, thus favoring interfibril cross-linking. Further, by specifying the intermixing of RGD-bearing peptides in 2-D and 3-D self-assemblies, the growth of HUVECs and NIH 3T3 cells could be significantly modulated. This approach may be immediately applicable toward a wide variety of self-assembling systems that form stable supramolecular structures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.