ArticlePflugers Archiv : European journal of physiology1990
Influence of pulsatile perfusion upon renin release from the isolated perfused rat kidney.
Article in Pflugers Archiv : European journal of physiology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- The renal baroreflex: A systematic review and meta-analysis in healthy and hypertensive animals.Physiological reports · 2025Pooled it
- Classical Renin-Angiotensin system in kidney physiology.Comprehensive Physiology · 2014Review
- Pressure induces intracellular calcium changes in juxtaglomerular cells in perfused afferent arterioles.Hypertension research : official journal of the Japanese Society of Hypertension · 2011Article
- Biomechanical coupling in renin-releasing cells.The Journal of clinical investigation · 1997Article
- Differential effect of neuropeptide-Y on membrane potential of cells in renal arterioles of the hydronephrotic mouse.The Journal of physiology · 1991Article
- Differential response of renin secretion to vasoconstrictors in the isolated perfused rat kidney.The Journal of physiology · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well established that renin release from the juxtaglomerular epithelioid cells in the media of the afferent arteriole strongly depends on the mean renal perfusion pressure, whereas a possible influence of the pulsation of blood pressure on renin release has only occasionally been investigated, and the results are contradictory. Such an influence on renin release cannot be excluded because pulsation is known to modulate arterial baroreceptors and vascular tone in some resistance vessels. In the isolated perfused rat kidney, we found a pulsation amplitude-dependent inhibition of renin release that could be blocked either by vasodilatation or by calcium channel blockade. The inhibition occurred at perfusion pressures between 85 and 125 mm Hg. The underlying pulsation pressure-sensitive mechanism has to be ascribed integrating properties, because a constant-flow pressure rise to the "systolic" value of pulsatile perfusion resulted in virtually the same inhibition of renin release. Moreover, a reduced urine flow during pulsatile perfusion provides evidence for preglomerular constriction under these conditions. It is concluded that, besides pathological changes of renal perfusion pressure, variations of the pulse amplitudes, e.g. resulting from renal artery stenosis or atherosclerosis, may also influence renin release and contribute to renovascular hypertension.
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