Evidence map›Paper›PMID 21863480›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2011

Genome-wide measurement of histone H3 replacement dynamics in yeast.

Oliver J Rando

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Oliver J RandoDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, USA. Oliver.Rando@umassmed.edu

Funding

Genomic analysis of histone replacement dynamics in yeastR01GM079205 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI RANDO, OLIVER J · 2008 to 2016
$3.3M
NIGMS NIH HHS GM079205NIGMS NIH HHS R01 GM079205
6 · The paper itself

Abstract

Chromatin plays critical roles in processes governed in different timescales - responses to environmental changes require rapid plasticity, while long-term stability through multiple cell generations requires epigenetically heritable chromatin. Understanding the dynamic behavior of chromatin is of great interest for fields ranging from transcriptional regulation through meiosis and gametogenesis. Here, we describe a protocol for measuring histone replacement rates genome wide in the budding yeast Saccharomyces cerevisiae. With suitable modifications, this protocol could be applied to other organisms, or to replacement dynamics of other DNA-associated proteins.

Indexed as

AnimalsCattleChromatin ImmunoprecipitationCulture TechniquesDNA, FungalFungal ProteinsGenome, FungalGenomicsHistonesIntestinesMicrococcal NucleaseNucleic Acid Amplification TechniquesNucleic Acid HybridizationNucleosomesOligonucleotide Array Sequence AnalysisPhosphoric Monoester HydrolasesDNA, FungalFungal ProteinsHistonesMicrococcal NucleaseNucleosomesPhosphoric Monoester HydrolasesRNA, Antisense

Identifiers

PMID21863480
PMCPMC3974389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.