SynthesisGerman medical science : GMS e-journal2011
Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis.
Synthesis in German medical science : GMS e-journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Effects of continuous positive airway pressure therapy duration on patients with obstructive sleep apnoea and type 2 diabetes mellitus: a systematic review and meta-analysis.BMJ open respiratory research · 2026Pooled it
- Effect of continuous positive airway pressure on glucose metabolism in adults with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2018Pooled it
- Effects of continuous positive airway pressure therapy on glycaemic control, insulin sensitivity and body mass index in patients with obstructive sleep apnoea and type 2 diabetes: a systematic review and meta-analysis.NPJ primary care respiratory medicine · 2015Pooled it
- Meta-analysis: continuous positive airway pressure improves insulin resistance in patients with sleep apnea without diabetes.Annals of the American Thoracic Society · 2013Pooled it
- Pooled it
- Mechanisms Linking Sleep-Disordered Breathing and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Article
- Potential Diagnostic and Monitoring Biomarkers of Obstructive Sleep Apnea-Umbrella Review of Meta-Analyses.Journal of clinical medicine · 2022Review
- Sleep Apnea and Serum Serotonin Level Pre- and Post-PAP Therapy: A Preliminary Study.Neurology and therapy · 2021Article
- Lifestyle Interventions Beyond Diet and Exercise for Patients With Nonalcoholic Fatty Liver Disease.Gastroenterology & hepatology · 2020Article
- Sleep Apnea, Obesity, and Disturbed Glucose Homeostasis: Epidemiologic Evidence, Biologic Insights, and Therapeutic Strategies.Current obesity reports · 2020Review
- Relationship Between Intermittent Hypoxia and Type 2 Diabetes in Sleep Apnea Syndrome.International journal of molecular sciences · 2019Review
- Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity.Diabetes & metabolism journal · 2019Review
- Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.Journal of diabetes research · 2018Article
- Sleep disturbances in women with polycystic ovary syndrome: prevalence, pathophysiology, impact and management strategies.Nature and science of sleep · 2018Review
- Omentin-A Novel Adipokine in Respiratory Diseases.International journal of molecular sciences · 2017Review
- VAMONOS (Veterans Affairs' Metabolism, Obstructed and Non-Obstructed Sleep) Study: Effects of CPAP Therapy on Glucose Metabolism in Patients with Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017Article
- Interactions between sleep, stress, and metabolism: From physiological to pathological conditions.Sleep science (Sao Paulo, Brazil) · 2015Review
- Effects of continuous positive airway pressure treatment on glycaemic control and insulin sensitivity in patients with obstructive sleep apnoea and type 2 diabetes: a meta-analysis.Archives of medical science : AMS · 2014Review
- Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives.Pulmonary medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObstructive Sleep Apnoea Syndrome (OSAS) is a condition of obstruction, apneas and arousals while sleeping. It has been suggested that OSAS independently influences glucose metabolism. The main treatment for OSAS is continuous positive airways pressure (CPAP).
objectivesTo assess the effects of CPAP on insulin resistance and glucose metabolism. SEARCH STRATEGY: We searched Medline, Embase and the Cochrane Controlled Trial Register (January 2010). SELECTION CRITERIA: We included randomised and non-randomised trials comparing CPAP with inactive control or placebo CPAP in adults with OSAS. DATA COLLECTION AND ANALYSIS: Two authors independently assessed trial quality and extracted data. Parallel and crossover group trials were analysed separately. A meta-analysis was carried out.
resultsThree parallel group and two cross-over randomised trials and one controlled trial were included investigating 296 participants. Sample sizes ranged from n=13 to n=102 participants, age was 18 to 75 years, mean body mass index (BMI) 27.2 kg/m² to 37.1 kg/m², mean apnoe hypopnoe index (AHI) 29.7 to 39.7 events per hour, mean dips >4% in arterial oxygen saturation per hour of sleep 1 to 42.7 events. The studies' methodological quality varied. Follow-up ranged from 4 to 12 weeks. Various endpoints were investigated. CPAP did neither influence plasma insulin levels nor HOMA-index, adiponectin levels or HbA1c value. One study reported a significant positive effect on the insulin sensitivity index (1.68%/min, 95% CI 0.3 to 3.06).
conclusionThis systematic review does not support the hypothesis that OSAS independently influences glucose metabolism. Sufficiently powered, long-term randomised controlled trials defining changes of insulin resistance as primary endpoint are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.