ArticleEuropean journal of clinical nutrition2012
Cross-sectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons.
Article in European journal of clinical nutrition, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Micronutrient intakes and potential inadequacies of community-dwelling older adults: a systematic review.The British journal of nutrition · 2015Pooled it
- A Randomized Controlled Trial to Examine the Effect of 2-Year Vitamin B12 and Folic Acid Supplementation on Physical Performance, Strength, and Falling: Additional Findings from the B-PROOF Study.Calcified tissue international · 2016Trial
- Homocysteine and the methylenetetrahydrofolate reductase 677C-->T polymorphism in relation to muscle mass and strength, physical performance and postural sway.European journal of clinical nutrition · 2013Trial
- Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function.Aging medicine (Milton (N.S.W)) · 2024Article
- Associations of serum vitamin B12 and its biomarkers with musculoskeletal health in middle-aged and older adults.Frontiers in endocrinology · 2024Article
- Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023Review
- Metabolomics analysis reveals serum biomarkers in patients with diabetic sarcopenia.Frontiers in endocrinology · 2023Article
- Association between Elevated Plasma Homocysteine and Low Skeletal Muscle Mass in Asymptomatic Adults.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Impact of Vitamin B12 Insufficiency on Sarcopenia in Community-Dwelling Older Korean Adults.International journal of environmental research and public health · 2021Article
- Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.The American journal of clinical nutrition · 2021Article
- Vitamin B-6 intake is related to physical performance in European older adults: results of the New Dietary Strategies Addressing the Specific Needs of the Elderly Population for Healthy Aging in Europe (NU-AGE) study.The American journal of clinical nutrition · 2021Article
- Associations Between Nutritional Deficits and Physical Performance in Community-Dwelling Older Adults.Frontiers in nutrition · 2021Article
- Health Risk, Functional Markers and Cognitive Status in Institutionalized Older Adults: A Longitudinal Study.International journal of environmental research and public health · 2020Article
- Dietary Intakes of Vegetable Protein, Folate, and Vitamins B-6 and B-12 Are Partially Correlated with Physical Functioning of Dutch Older Adults Using Copula Graphical Models.The Journal of nutrition · 2020Article
- Functionality of patients with post-stroke hemiplegia: Does serum folate level matter?Turkish journal of physical medicine and rehabilitation · 2019Article
- Sport Nutrigenomics: Personalized Nutrition for Athletic Performance.Frontiers in nutrition · 2019Review
- Relationship between Homocysteine and Muscle Strength Decline: The Baltimore Longitudinal Study of Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Vitamin B12 deficiency and impaired expression of amnionless during aging.Journal of cachexia, sarcopenia and muscle · 2018Article
- Low-grade systemic inflammation is associated with functional disability in elderly people affected by dementia.GeroScience · 2018Article
- Reduced dietary intake of micronutrients with antioxidant properties negatively impacts muscle health in aged mice.Journal of cachexia, sarcopenia and muscle · 2018Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesDecreases in physical performance are associated with multiple negative health outcomes. The objective of this study was to examine whether high plasma homocysteine and low serum vitamin B12 are independent risk factors for lower physical performance, both cross-sectionally and longitudinally. SUBJECTS/
methodsThis study was performed in persons aged ≥65 years of the LASA (Longitudinal Aging Study Amsterdam), an ongoing cohort study. Blood was collected in 1995/1996 (n=1352). Physical performance was assessed in 1995/1996 and in 1998/1999 using three tests: the walking test, the chair stands test and the tandem stand (n=901-1155).
resultsAfter adjustment for confounding, women in the highest quartile of homocysteine had a significantly lower physical performance than did those in the lowest quartile in the cross-sectional analyses (β=-0.93, s.e.=0.34, P<0.01). This association was borderline statistically significant in the longitudinal analyses (β=-0.69, s.e.=0.35, P=0.05). After additional adjustment for serum vitamin B12, both associations were statistically significant (P<0.05). For vitamin B12 in women, and for homocysteine and vitamin B12 in men, the observed associations were less consistent.
conclusionsHigh plasma homocysteine is an independent risk factor for lower physical performance in older women. The association between vitamin B12 and physical performance is less clear.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.