ArticleJournal of physics. Condensed matter : an Institute of Physics journal2011
Model of myosin node aggregation into a contractile ring: the effect of local alignment.
Article in Journal of physics. Condensed matter : an Institute of Physics journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- The Myosin-V Myo51 and Alpha-Actinin Ain1p Cooperate during Contractile Ring Assembly and Disassembly in Fission Yeast Cytokinesis.Journal of fungi (Basel, Switzerland) · 2024Article
- Animal Cell Cytokinesis: The Rho-Dependent Actomyosin-Anilloseptin Contractile Ring as a Membrane Microdomain Gathering, Compressing, and Sorting Machine.Frontiers in cell and developmental biology · 2020Article
- Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.BMC molecular and cell biology · 2019Article
- Molecular mechanisms of contractile-ring constriction and membrane trafficking in cytokinesis.Biophysical reviews · 2018Review
- Nanoscale architecture of theeLife · 2017Article
- The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast.Molecular biology of the cell · 2016Article
- The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis.Molecular biology of the cell · 2015Article
- Formation of contractile networks and fibers in the medial cell cortex through myosin-II turnover, contraction, and stress-stabilization.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Dynamic network morphology and tension buildup in a 3D model of cytokinetic ring assembly.Biophysical journal · 2014Article
- The value of mechanistic biophysical information for systems-level understanding of complex biological processes such as cytokinesis.Biophysical journal · 2014Review
- Pom1 regulates the assembly of Cdr2-Mid1 cortical nodes for robust spatial control of cytokinesis.The Journal of cell biology · 2014Article
- Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis.Molecular biology of the cell · 2013Article
- Contractile-ring assembly in fission yeast cytokinesis: Recent advances and new perspectives.Cytoskeleton (Hoboken, N.J.) · 2012Review
- α-Actinin and fimbrin cooperate with myosin II to organize actomyosin bundles during contractile-ring assembly.Molecular biology of the cell · 2012Article
- Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.Molecular biology of the cell · 2012Article
- INSIGHTS INTO THE MECHANICS OF CYTOKINETIC RING ASSEMBLY USING 3D MODELING.International Mechanical Engineering Congress and Exposition : [proceedings]. International Mechanical Engineering Congress and ExpositionArticle
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3 authors at 2 institutions in 1 country.
Funding
Abstract
Actomyosin bundles frequently form through aggregation of membrane-bound myosin clusters. One such example is the formation of the contractile ring in fission yeast from a broad band of cortical nodes. Nodes are macromolecular complexes containing several dozens of myosin-II molecules and a few formin dimers. The condensation of a broad band of nodes into the contractile ring has been previously described by a search, capture, pull and release (SCPR) model. In SCPR, a random search process mediated by actin filaments nucleated by formins leads to transient actomyosin connections among nodes that pull one another into a ring. The SCPR model reproduces the transport of nodes over long distances and predicts observed clump-formation instabilities in mutants. However, the model does not generate transient linear elements and meshwork structures as observed in some wild-type and mutant cells during ring assembly. As a minimal model of node alignment, we added short-range aligning forces to the SCPR model representing currently unresolved mechanisms that may involve structural components, cross-linking and bundling proteins. We studied the effect of the local node alignment mechanism on ring formation numerically. We varied the new parameters and found viable rings for a realistic range of values. Morphologically, transient structures that form during ring assembly resemble those observed in experiments with wild-type and cdc25-22 cells. Our work supports a hierarchical process of ring self-organization involving components drawn together from distant parts of the cell followed by progressive stabilization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.