Evidence map›Paper›PMID 21862829›Full record

Trial reportPsychosomatic medicine2011

Interacting effects of trait anger and acute anger arousal on pain: the role of endogenous opioids.

Stephen Bruehl, John W Burns, Ok Yung Chung, Melissa Chont

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychosomatic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04744883 (Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04744883 early_phase1active not recruitingnot on this mapstarted 2020, after this paper: background citation

Evaluating Specific and Non-Specific Mechanisms in Two Distinct Complementary/Integrative Interventions for Chronic Pain

TypeinterventionalSponsorRush University Medical CenterRan2020 to 2026Enrolled140ConditionsChronic Low-back PainArmsSpinal Manipulation Therapy (SMT), Naloxone, Placebo, Mindfulness Based Stress Reduction Therapy (MT)
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  8. Article
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  10. Expectancy Effects on Conditioned Pain Modulation Are Not Influenced by Naloxone or Morphine.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2016
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  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Stephen BruehlVanderbilt University Medical Center, 701 Medical Arts Bldg, 1211 21st Ave S, Nashville, TN 37212, USA. Stephen.Bruehl@vanderbilt.edu
John W Burns
Ok Yung Chung
Melissa Chont
Vanderbilt University Medical Center · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Anger Expression, Opioid Dysfunction, and Chronic PainR01NS050578 · NINDS · VANDERBILT UNIVERSITY · PI BRUEHL, STEPHEN · 2006 to 2009
$1.3M
NCRR NIH HHS 1UL1 RR024975NCRR NIH HHS UL1 RR024975NINDS NIH HHS R01 NS050578NINDS NIH HHS R01-NS050578
6 · The paper itself

Abstract

objectiveElevated trait anger (TRANG; heightened propensity to experience anger) is associated with greater pain responsiveness, possibly via associations with deficient endogenous opioid analgesia. This study tested whether acute anger arousal moderates the impact of TRANG on endogenous opioid analgesia.

methodsNinety-four chronic low back pain (LBP) participants and 85 healthy controls received opioid blockade (8 mg of naloxone) or placebo in a randomized, counterbalanced order in separate sessions. Participants were randomly assigned to undergo either a 5-minute anger recall interview (ARI) or a neutral control interview across both drug conditions. Immediately after the assigned interview, participants engaged sequentially in finger pressure and ischemic forearm pain tasks. Opioid blockade effects were derived (blockade minus placebo condition pain ratings) to index opioid antinociceptive function.

resultsPlacebo condition TRANG by interview interactions (p values < .05) indicated that TRANG was hyperalgesic only in the context of acute anger arousal (ARI condition; p values < .05). Blockade effect analyses suggested that these hyperalgesic effects were related to deficient opioid analgesia. Significant TRANG by interview interactions (p values < .05) for both pain tasks indicated that elevated TRANG was associated with smaller blockade effects (less endogenous opioid analgesia) only in the ARI condition (p values < .05). Results for ischemic task visual analog scale intensity blockade effects suggested that associations between TRANG and impaired opioid function were most evident in LBP participants when experiencing anger (type by interview by TRANG interaction; p < .05).

conclusionsResults indicate that hyperalgesic effects of TRANG are most prominent when acute anger is aroused and suggest that endogenous opioid mechanisms contribute.

Indexed as

AdultAngerArousalCross-Over StudiesDouble-Blind MethodFemaleHumansLow Back PainMaleNaloxoneNarcotic AntagonistsOpioid PeptidesPainPain MeasurementPersonality InventoryNaloxoneNarcotic AntagonistsOpioid Peptides

Identifiers

PMID21862829
PMCPMC3167026
OpenAlexW2024325905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.