ArticleDevelopment (Cambridge, England)2011
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
Article in Development (Cambridge, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Tbx16 and mesogenin 1 promote presomitic mesoderm differentiation by repressing the mesodermal progenitor cell state.PLoS genetics · 2026Article
- Two distinct modes of Vgll4-mediated Tead regulation control organ size in zebrafish.Communications biology · 2026Article
- Reproductive-state dependent changes in inner ear gene expression in female plainfin midshipman fish.PloS one · 2026Article
- Decreased expression of LEF1 caused defective decidualization by inhibiting IL-11 expression in patients with adenomyosis.Molecular medicine (Cambridge, Mass.) · 2025Article
- wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Article
- Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions.Frontiers in cell and developmental biology · 2020Article
- Shootins mediate collective cell migration and organogenesis of the zebrafish posterior lateral line system.Scientific reports · 2019Article
- Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells.Current biology : CB · 2019Article
- Urban stormwater runoff negatively impacts lateral line development in larval zebrafish and salmon embryos.Scientific reports · 2018Article
- Using Zebrafish to Study Collective Cell Migration in Development and Disease.Frontiers in cell and developmental biology · 2018Review
- Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues.NPJ Regenerative medicine · 2018Article
- A framework for understanding morphogenesis and migration of the zebrafish posterior Lateral Line primordium.Mechanisms of development · 2017Review
- Lef1-dependent hypothalamic neurogenesis inhibits anxiety.PLoS biology · 2017Article
- Article
- Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling.Development (Cambridge, England) · 2016Article
- Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.Biology open · 2015Article
- Article
- Making sense of Wnt signaling-linking hair cell regeneration to development.Frontiers in cellular neuroscience · 2015Review
- slc7a6os gene plays a critical role in defined areas of the developing CNS in zebrafish.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The zebrafish posterior lateral line (pLL) is a sensory system that comprises clusters of mechanosensory organs called neuromasts (NMs) that are stereotypically positioned along the surface of the trunk. The NMs are deposited by a migrating pLL primordium, which is organized into polarized rosettes (proto-NMs). During migration, mature proto-NMs are deposited from the trailing part of the primordium, while progenitor cells in the leading part give rise to new proto-NMs. Wnt signaling is active in the leading zone of the primordium and global Wnt inactivation leads to dramatic disorganization of the primordium and a loss of proto-NM formation. However, the exact cellular events that are regulated by the Wnt pathway are not known. We identified a mutant strain, lef1(nl2), that contains a lesion in the Wnt effector gene lef1. lef1(nl2) mutants lack posterior NMs and live imaging reveals that rosette renewal fails during later stages of migration. Surprisingly, the overall primordium patterning, as assayed by the expression of various markers, appears unaltered in lef1(nl2) mutants. Lineage tracing and mosaic analyses revealed that the leading cells (presumptive progenitors) move out of the primordium and are incorporated into NMs; this results in a decrease in the number of proliferating progenitor cells and eventual primordium disorganization. We concluded that Lef1 function is not required for initial primordium organization or migration, but is necessary for proto-NM renewal during later stages of pLL formation. These findings revealed a novel role for the Wnt signaling pathway during mechanosensory organ formation in zebrafish.
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