Trial reportClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2012
A shared low-frequency oscillatory rhythm abnormality in resting and sensory gating in schizophrenia.
Trial report in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Modafinil effects on middle-frequency oscillatory power during rule selection in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Quantitative electroencephalography as a potential neurophysiological diagnostic biomarker of schizophrenia and first-episode psychosis: a systematic review of clinical implications.Frontiers in psychiatry · 2026Review
- Article
- A multivariate approach to investigate the associations of electrophysiological indices with schizophrenia clinical and functional outcome.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research.Biomedicines · 2022Review
- Cannabis Vapor Exposure Alters Neural Circuit Oscillatory Activity in a Neurodevelopmental Model of Schizophrenia: Exploring the Differential Impact of Cannabis Constituents.Schizophrenia bulletin open · 2022Article
- A multimodal magnetoencephalography 7 T fMRI and 7 T proton MR spectroscopy study in first episode psychosis.NPJ schizophrenia · 2020Article
- Investigating functional changes in the brain to intermittently induced auditory illusions and its relevance to chronic tinnitus.Human brain mapping · 2020Article
- Alterations in resting-state gamma activity in patients with schizophrenia: a high-density EEG study.European archives of psychiatry and clinical neuroscience · 2019Article
- Visual Attention Deficits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex.Computational psychiatry (Cambridge, Mass.) · 2018Article
- Identifying auditory cortex encoding abnormalities in schizophrenia: The utility of low-frequency versus 40 Hz steady-state measures.Psychophysiology · 2018Article
- EEG Frequency Bands in Psychiatric Disorders: A Review of Resting State Studies.Frontiers in human neuroscience · 2018Review
- Decoding Saccadic Directions Using Epidural ECoG in Non-Human Primates.Journal of Korean medical science · 2017Article
- Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.Psychological medicine · 2017Article
- Frontal slow-wave activity as a predictor of negative symptoms, cognition and functional capacity in schizophrenia.The British journal of psychiatry : the journal of mental science · 2016Article
- Effects of Ketamine on Resting-State EEG Activity and Their Relationship to Perceptual/Dissociative Symptoms in Healthy Humans.Frontiers in pharmacology · 2016Article
- Positive and Negative Symptoms in Schizophrenia Relate to Distinct Oscillatory Signatures of Sensory Gating.Frontiers in human neuroscience · 2016Article
- Abnormal visuomotor processing in schizophrenia.NeuroImage. Clinical · 2016Article
- Multivariate genetic determinants of EEG oscillations in schizophrenia and psychotic bipolar disorder from the BSNIP study.Translational psychiatry · 2015Article
- Delta frequency optogenetic stimulation of the thalamic nucleus reuniens is sufficient to produce working memory deficits: relevance to schizophrenia.Biological psychiatry · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectivesWe hypothesized that an oscillatory abnormality that is consistently observed across various testing paradigms may index an elementary neuronal abnormality marking schizophrenia risk.
methodsCompared neural oscillations in resting EEG and sensory gating conditions in schizophrenia patients (n=128), their first-degree relatives (n=80), and controls (n=110) and calculated phenotypic and/or genetic correlation of the abnormal measure across these conditions.
resultsUsing a uniform, single trial analytical approach, we identified two prominent oscillatory characteristics in schizophrenia: (1) augmented neural oscillatory power was pervasive in medicated schizophrenia patients in most frequencies, most prominent in the theta-alpha range (4-11 Hz) across the two paradigms (all p<0.007); and (2) their first-degree relatives shared significantly augmented oscillatory energy in theta-alpha frequency in resting (p=0.002) and insufficient suppression of theta-alpha in sensory gating (p=0.01) compared with normal controls. Heritability estimates for theta-alpha related measures for resting and gating conditions ranged from 0.44 to 0.49 (p<0.03). The theta-alpha measures were correlated genetically with each other (RhoG=0.82±0.43; p<0.05).
conclusionsAugmented theta-alpha rhythm may be an elementary neurophysiological problem associated with genetic liability of schizophrenia. SIGNIFICANCE: This finding helps to refine key electrophysiologic biomarkers for genetic and clinical studies of schizophrenia.
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