ArticleAtherosclerosis2011
Activation of human vascular cells decreases their expression of transforming growth factor-beta.
Article in Atherosclerosis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Understanding interleukin 11 as a disease gene and therapeutic target.The Biochemical journal · 2023Review
- Roles and mechanism of IL-11 in vascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Interleukin-35 Levels in Patients with Stable Coronary Artery Disease.Arquivos brasileiros de cardiologia · 2022Article
- A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model.Scientific reports · 2021Article
- Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models.Scientific reports · 2020Article
- Targeting cardiac fibrosis in heart failure with preserved ejection fraction: mirage or miracle?EMBO molecular medicine · 2020Review
- Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.Atherosclerosis · 2017Article
- Further Evidence Supporting a Protective Role of Transforming Growth Factor-β (TGFβ) in Aortic Aneurysm and Dissection.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Glucose and acute exercise influence factors secreted by circulating angiogenic cells in vitro.Physiological reports · 2016Article
- Tobacco smoking is associated with methylation of genes related to coronary artery disease.Clinical epigenetics · 2015Article
- Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.The Journal of clinical investigation · 2014Article
- TIPE2 deficiency accelerates neointima formation by downregulating smooth muscle cell differentiation.Cell cycle (Georgetown, Tex.) · 2013Article
- Participation of blood vessel cells in human adaptive immune responses.Trends in immunology · 2012Review
- Decreased plasma IL-35 levels are related to the left ventricular ejection fraction in coronary artery diseases.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveDespite pro-fibrotic effects, transforming growth factor (TGF)-β prevents arteriosclerosis by suppressing effector leukocytes and promoting smooth muscle differentiation. However, previous observations of increased TGF-β expression in arteriosclerotic plaques are not consistent with that of an effective protective factor. We investigated the expression, regulation, and responses of TGF-β in human arterial tissues and cells. METHODS AND
resultsThe expression of TGF-β by intrinsic vascular cells was lower in arteriosclerotic than non-diseased coronary arteries. Activation of resident and infiltrating leukocytes did not elicit TGF-β production from coronary artery segments in organ culture. Instead, the basal expression of TGF-β by coronary arteries decreased after vessel procurement and ex vivo culture. Activation of cultured smooth muscle cells and endothelial cells with phorbol ester and ionophore also decreased TGF-β expression. Isolated cell types representing those found in the artery wall were all capable of signaling in response to TGF-β, however production of the cytoprotective molecule, interleukin-11 was cell type-dependent and restricted to smooth muscle cells and fibroblasts. Interleukin-11 reduced smooth muscle cell apoptosis to T cell effectors.
conclusionsInflammation and cellular activation diminish the basal expression of TGF-β by quiescent human vascular cells. Induction of interleukin-11 may contribute to the anti-arteriosclerotic actions of TGF-β.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.