ArticleStem cells and development2012
Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family.
Article in Stem cells and development, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- The pro-angiogenesis effect of miR33a-5p/Ets-1/DKK1 signaling in ox-LDL induced HUVECs.International journal of biological sciences · 2021Article
- The microRNA/TET3/REST axis is required for olfactory globose basal cell proliferation and male behavior.EMBO reports · 2020Article
- Review
- The miR-200-Quaking axis functions in tumour angiogenesis.Oncogene · 2019Article
- Non-coding RNA in endothelial-to-mesenchymal transition.Cardiovascular research · 2019Review
- Article
- Paragangliomas arise through an autonomous vasculo-angio-neurogenic program inhibited by imatinib.Acta neuropathologica · 2018Article
- ZEB1-repressed microRNAs inhibit autocrine signaling that promotes vascular mimicry of breast cancer cells.Oncogene · 2018Article
- PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment.Journal of translational medicine · 2016Article
- MiRNA-200b Regulates RMP7-Induced Increases in Blood-Tumor Barrier Permeability by Targeting RhoA and ROCKII.Frontiers in molecular neuroscience · 2016Article
- The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy.Oncotarget · 2015Review
- An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinoma.BMC molecular biology · 2015Article
- Role of microRNAs in maintaining cancer stem cells.Advanced drug delivery reviews · 2015Review
- Snail1-dependent control of embryonic stem cell pluripotency and lineage commitment.Nature communications · 2014Article
- A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review).Oncology letters · 2013Article
- Article
- MicroRNA-200a regulates Grb2 and suppresses differentiation of mouse embryonic stem cells into endoderm and mesoderm.PloS one · 2013Article
- Article
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the transcription factor Snail is required for normal vasculogenesis in the developing mouse embryo. In addition, tumors expressing Snail have been associated with a more malignant phenotype, with both increased invasive properties and angiogenesis. Although the relationship between Snail and vasculogenesis has been noted, no mechanistic analysis has been elucidated. Here, we show that in addition to inducing an epithelial mesenchymal transition, Snail promotes the cell-autonomous induction of Flk1(+) endothelial cells in an early subset of differentiating mouse embryonic stem (ES) cells. Cells that become Flk1+ in response to Snail have a transcriptional profile specific to Gata6+primitive endoderm, but not the early Nanog+epiblast. We further show that Snail's ability to promote Flk1(+) endothelium depends on fibroblast growth factor signaling as well as the repression of the microRNA-200 (miR-200) family, which directly targets the 3' UTRs of Flk1 and Ets1. Together, our results show that Snail is capable of inducing Flk1+ lineage commitment in a subset of differentiating ES cells through the down-regulation of the miR-200 family. We hypothesize that this mechanism of Snail-induced vasculogenesis may be conserved in both the early developing embryo and malignant cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.