ArticlePituitary2012
Growth hormone and proopiomelanocortin are targeted by autoantibodies in a patient with biopsy-proven IgG4-related hypophysitis.
Article in Pituitary, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Unveiling the Etiopathogenic Spectrum of Hypophysitis: A Narrative Review.Journal of personalized medicine · 2023Review
- Progress and Challenges of Immune Checkpoint Inhibitor-Induced Hypophysitis.Journal of clinical medicine · 2023Review
- Autoantibody reactivity profile of primary autoimmune hypophysitis patients: preliminary results.Endocrine · 2022Article
- Sellar germinoma mimicking IgG4-related hypophysitis: a case report.BMC endocrine disorders · 2022Article
- Molecular and Genetic Immune Biomarkers of Primary and Immune-Therapy Induced Hypophysitis: From Laboratories to the Clinical Practice.Journal of personalized medicine · 2021Review
- Markers of humoral and cell-mediated immune response in primary autoimmune hypophysitis: a pilot study.Endocrine · 2021Article
- Anti-pituitary antibodies and susceptible human leukocyte antigen alleles as predictive biomarkers for pituitary dysfunction induced by immune checkpoint inhibitors.Journal for immunotherapy of cancer · 2021Article
- Article
- Cancer immunotherapy - immune checkpoint blockade and associated endocrinopathies.Nature reviews. Endocrinology · 2017Review
- Diagnosis and management of tumor-like hypophysitis: A retrospective case series.Oncology letters · 2016Article
- Thickened Pituitary Stalk Associated with a Mass in the Sphenoidal Sinus: An Alarm to Suspect Hypophysitis by Immunoglobulin G4?International archives of otorhinolaryngology · 2015Article
- Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis.Pituitary · 2014Article
- Opportunistic Autoimmune Disorders Potentiated by Immune-Checkpoint Inhibitors Anti-CTLA-4 and Anti-PD-1.Frontiers in immunology · 2014Review
- Purification of pituitary autoantigen by column liquid chromatography and chromatofocusing.Central-European journal of immunology · 2014Article
- Prevalence of antipituitary antibodies in acromegaly.Pituitary · 2012Article
- Pituitary autoimmune disease: nuances in clinical presentation.Endocrine · 2012Review
- Pituitary antibodies in women with Hashimoto's thyroiditis: prevalence in diagnostic and prediagnostic sera.Thyroid : official journal of the American Thyroid Association · 2012Article
- Hypophysitis induced by monoclonal antibodies to cytotoxic T lymphocyte antigen 4: challenges from a new cause of a rare disease.The oncologist · 2012Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Hypophysitis is a chronic inflammation of the pituitary gland often caused by autoimmunity. Among the autoimmune diseases it is one of the few where the autoantigens remain to be identified. The goal of the paper was to characterize the antigenic profile in a previously reported patient with IgG4-related hypophysitis. Immunofluorescence and immunoblotting were performed to detect antibodies to human pituitary proteins. The proteins recognized by western blotting were then submitted to mass spectrometry for sequencing. The patient's autoantibodies recognized two unique bands around 40 and 30 kDa on immunoblotting. Sequencing revealed one peptide from proopiomelanocortin in the 40 kDa band and four peptides from growth hormone in the 30 kDa band. This work represents the first antigenic profile in IgG4-related hypophysitis, and the first recognition of proopiomelanocortin as a possible pituitary autoantigen. In addition, the work supports previous suggestions of growth hormone as a pituitary autoantigen. Further studies are needed to prove the pathogenicity and diagnostic utility of these two pituitary proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.