ReviewReviews in endocrine & metabolic disorders2012
Mechanism of action of 1,25-dihydroxyvitamin D3 on intestinal calcium absorption.
Review in Reviews in endocrine & metabolic disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Dairy intake and risk of hip fracture in prospective cohort studies: non-linear algorithmic dose-response analysis in 486 950 adults.Journal of nutritional science · 2023Pooled it
- Vitamin D-Related Risk Factors for Maternal Morbidity and Mortality during Pregnancy: Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.The Cochrane database of systematic reviews · 2020Pooled it
- Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth.The New England journal of medicine · 2018Trial
- Comparative Evaluation of Chemically Synthesized and Biosynthesized 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2026Article
- Mechanistic Insights into Milk Minerals Driving Bone Development and Mineralization in Growing Rats.Nutrients · 2026Article
- Early-Phase Response of Broiler Breeders to 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2026Article
- Wubi Shanyao pills ameliorate diet-induced postmenopausal osteoporosis in mice by enhancing calcium absorption.Frontiers in pharmacology · 2025Article
- Calcium, Potassium, Sodium, and Magnesium Concentrations in the Placenta, Umbilical Cord, and Fetal Membrane from Women with Multiple Pregnancies.Life (Basel, Switzerland) · 2023Article
- Differentiation of Dihydroxylated Vitamin DJournal of the American Society for Mass Spectrometry · 2022Article
- The Effects of Vitamins and Micronutrients onJournal of immunology research · 2022Review
- Molecular Mechanisms of Vitamin D-Mediated Immunomodulation.Galen medical journal · 2021Article
- Glycocholic acid and butyrate synergistically increase vitamin D-induced calcium uptake in Caco-2 intestinal epithelial cell monolayers.Bone reports · 2020Article
- Calcium citrate: from biochemistry and physiology to clinical applications.Reviews in endocrine & metabolic disorders · 2019Review
- Factors inhibiting intestinal calcium absorption: hormones and luminal factors that prevent excessive calcium uptake.The journal of physiological sciences : JPS · 2019Review
- TRPV6 and CaCellular and molecular gastroenterology and hepatology · 2019Article
- Hepatic Transport of 25-Hydroxyvitamin DDrug metabolism and disposition: the biological fate of chemicals · 2018Article
- Time Course of Vitamin D Depletion and Repletion in Reproductive-age Female C57BL/6 Mice.Comparative medicine · 2017Article
- Simultaneous quantification of 25-hydroxyvitamin DJournal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2017Article
- The calcium and vitamin D controversy.Therapeutic advances in musculoskeletal disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the major controlling hormone of intestinal calcium absorption. As the body's demand for calcium increases from a diet deficient in calcium, from growth, pregnancy or lactation, the synthesis of 1,25(OH)(2)D(3) is increased resulting in the stimulation of intestinal calcium absorption. However a complete description of the molecular mechanisms involved in the 1,25(OH)(2)D(3) regulated calcium absorptive process remains incomplete. Intestinal calcium absorption occurs by both an active saturable transcellular pathway and a passive nonsaturable paracellular pathway. Each step in the process of transcellular calcium transport (apical entry of calcium, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the plasma membrane pump) has been reported to involve a vitamin D dependent component. This article will review recent studies, including those using knockout mice, that have suggested that 1,25(OH)(2)D(3) mediated calcium absorption is more complex than the traditional three step model of transcellular calcium transport. Current concepts are reviewed and questions that remain are addressed. Evidence for a role of 1,25(OH)(2)D(3) in the regulation of the paracellular pathway is also discussed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.