ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2011
Rectification of the current in alpha-hemolysin pore depends on the cation type: the alkali series probed by MD simulations and experiments.
Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Improving All-Atom Molecular Dynamics Models for Quantitative Prediction of Nanopore Blockade Current.bioRxiv : the preprint server for biology · 2026Article
- Bioinformatic and computational biophysics tools for nanopore engineering: a review from standard approaches to machine learning advancements.Journal of nanobiotechnology · 2026Review
- Dissecting current rectification through asymmetric nanopores.Biophysical journal · 2025Article
- Electro-osmotic Flow Generation via a Sticky Ion Action.ACS nano · 2024Article
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- Electro-Osmotic Flow Generation via a Sticky Ion Action.bioRxiv : the preprint server for biology · 2023Article
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- Laser-based temperature control to study the roles of entropy and enthalpy in polymer-nanopore interactions.Science advances · 2021Article
- Molecular Transport across the Ionic Liquid-Aqueous Electrolyte Interface in a MoSACS applied materials & interfaces · 2020Article
- Ionic transport through a protein nanopore: a Coarse-Grained Molecular Dynamics Study.Scientific reports · 2019Article
- Alpha-hemolysin nanopore allows discrimination of the microcystins variants.RSC advances · 2019Article
- Insights into protein sequencing with an α-Hemolysin nanopore by atomistic simulations.Scientific reports · 2019Article
- A lithium-ion-active aerolysin nanopore for effectively trapping long single-stranded DNA.Chemical science · 2019Article
- Colloquium: Ionic phenomena in nanoscale pores through 2D materials.Reviews of modern physics · 2019Article
- Comparative biosensing of glycosaminoglycan hyaluronic acid oligo- and polysaccharides using aerolysin andThe European physical journal. E, Soft matter · 2018Article
- Article
- The aerolysin nanopore: from peptidomic to genomic applications.Nanoscale · 2018Review
- MOLEonline: a web-based tool for analyzing channels, tunnels and pores (2018 update).Nucleic acids research · 2018Article
- Golden aspect ratio for ion transport simulation in nanopores.Physical review. E · 2018Article
- Membrane Position Dependency of the pKThe Journal of membrane biology · 2018Article
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7 authors.
Funding
Abstract
A striking feature of the alpha-hemolysin channel-a prime candidate for biotechnological applications-is the dependence of its ionic conductance on the magnitude and direction of the applied bias. Through a combination of lipid bilayer single-channel recording and molecular dynamics (MD) simulations, we characterized the current-voltage relationship of alpha-hemolysin for all alkali chloride salts at neutral pH. The rectification of the ionic current was found to depend on the type of cations and increase from Li(+) to Cs(+). Analysis of the MD trajectories yielded a simple quantitative model that related the ionic current to the electrostatic potential, the concentration and effective mobility of ions in the channel. MD simulations reveal that the major contribution to the current asymmetry and rectification properties originates from the cationic contribution to the current that is significantly reduced in a cationic dependent way when the membrane polarity is reversed. The variation of chloride current was found to be less important. We report that the differential affinity of cations for the charged residues positioned at the channel's end modulates the number of ions inside the channel stem thus affecting the current properties. Through direct comparison of simulation and experiment, this study evaluates the accuracy of the MD method for prediction of the asymmetric, voltage dependent conductances of a membrane channel.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.