ArticleInternational journal of pediatric endocrinology2011
Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient.
Article in International journal of pediatric endocrinology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Interventions to improve vitamin D status in at-risk ethnic groups during pregnancy and early childhood: a systematic review.Public health nutrition · 2021Pooled it
- The change in plasma 25-hydroxyvitamin D did not differ between breast-fed infants that received a daily supplement of ergocalciferol or cholecalciferol for 3 months.The Journal of nutrition · 2013Trial
- Assessment of Micronutrient Deficiencies in Exclusively Breastfed Infants: A Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- How Vitamin D Levels of Children Changed During COVID-19 Pandemic: A Comparison of Pre-pandemic and Pandemic PeriodsJournal of clinical research in pediatric endocrinology · 2022Article
- The Effect of Vitamin D Prophylaxis on 25-OH Vitamin D Levels in Children.Turkish archives of pediatrics · 2021Article
- Bone health in pediatric patients with neurological disorders.Annals of pediatric endocrinology & metabolism · 2020Article
- How should we give vitamin D supplementation? evaluation of the pediatricians' knowledge in Turkey.Italian journal of pediatrics · 2017Article
- Attitudes of Pediatricians Regarding Prevention and Treatment of Vitamin D Deficiency.Journal of clinical research in pediatric endocrinology · 2016Article
- Factors Influencing Serum Vitamin D Concentration in Turkish Children Residing in İzmir: A Single-Center Experience.Journal of clinical research in pediatric endocrinology · 2015Article
- Preventable but neglected: rickets in an informal settlement, Nairobi, Kenya.Public health action · 2014Article
- Vitamin D deficiency in a tropical country--treatment and prevention in children.Indian journal of pediatrics · 2014Review
- Vitamin D deficiency in infants aged 1 to 6 months.Korean journal of pediatrics · 2013Article
- The vitamin D grey areas in pediatric primary care. Very low serum 25-hydroxyvitamin D levels in asymptomatic children living in northeastern Italy.International journal of pediatric endocrinology · 2012Article
- Prevention and Treatment of Vitamin D Deficiency in India: An Expert Group Consensus.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryAIM-
objectiveVitamin D deficiency and rickets in developing countries continues to be a major health problem. Additionally, the increase of cases of rickets in children of some ethnic groups in the United States and European countries has provided this issue to be updated. Obviously, powerful strategies are necessary to prevent vitamin D deficiency nation-wide. In 2005, a nationwide prevention program for vitamin D deficiency was initiated, recommending 400 IU vitamin D per a day. This study was designed to evaluate the efficacy of the prevention program.
methodsEighty-five infants who were recalled as part of the national screening program for congenital hypothyroidism between February 2010 and August 2010 at Kocaeli University Children's Hospital were evaluated in terms of their vitamin D status as well. All babies had been provided with free vitamin D (Cholecalciferol) solution and recommended to receive 400 IU (3 drops) daily. Information regarding the age at start of supplementation, the dosage and compliance were obtained from the mothers with face-to-face interview. Serum 25-hydroxy vitamin D (25-OH-D), alkaline phosphatase (AP), parathormone (PTH) levels were measured.
resultsThe mean age at which Vitamin D3 supplementation began was 16.5 ± 20.7 (3-120) days. Ninety percent of cases (n:76) were receiving 3 drops (400 IU) vitamin D3 per day as recommended; 70% of cases (n:59) were given vitamin D3 regularly, the remainder had imperfect compliance. Among those children who are older than 12 months, only 20% continued vitamin D supplementation. No subject had clinical signs of rickets. The mean 25-OH-D level was 42,5 ± 25,8 (median: 38.3) ng/ml. Ten subjects (12%) had their serum 25-OH-D levels lower than 20 ng/ml (6 between 15-20 ng/ml, 3 between 5-15 ng/ml and only one < 5 ng/ml).
conclusions400 U/day vitamin D seems adequate to prevent vitamin D deficiency. However, we believe that the program for preventing vitamin D deficiency in Turkey, needs to be reinforced to start immediately after birth, and to continue beyond 1 year of age at 400U regular daily dosage.
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