ArticleThe Journal of cell biology1990
Mapping enteroendocrine cell populations in transgenic mice reveals an unexpected degree of complexity in cellular differentiation within the gastrointestinal tract.
Article in The Journal of cell biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 114 citations in OpenAlex.
- The chemical brain hypothesis for the origin of nervous systems.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Expression patterns of L-amino acid receptors in the murine STC-1 enteroendocrine cell line.Cell and tissue research · 2019Article
- Limited gut cell repertoire for multiple hormones.Nature cell biology · 2018Article
- Mast Cells and Serotonin Synthesis Modulate Chagas Disease in the Colon: Clinical and Experimental Evidence.Digestive diseases and sciences · 2018Article
- Lipid-rich diet enhances L-cell density in obese subjects and in mice through improved L-cell differentiation.Journal of nutritional science · 2015Article
- Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.PloS one · 2013Article
- Microbial translocation across the GI tract.Annual review of immunology · 2012Review
- Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.The Journal of comparative neurology · 2011Article
- Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation.Diabetes, obesity & metabolism · 2011Review
- Molecular modulation of intestinal epithelial barrier: contribution of microbiota.Journal of biomedicine & biotechnology · 2010Review
- Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Enteroendocrine cells express functional Toll-like receptors.American journal of physiology. Gastrointestinal and liver physiology · 2007Article
- Intestinal dysplasia induced by simian virus 40 T antigen is independent of p53.Journal of virology · 2005Article
- Hic-5 regulates an epithelial program mediated by PPARgamma.Genes & development · 2005Article
- Changes in small intestinal homeostasis, morphology, and gene expression during rotavirus infection of infant mice.Journal of virology · 2003Article
- Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium.The EMBO journal · 2002Article
- Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology.Microbiology and molecular biology reviews : MMBR · 1998Review
- The diet and gut microflora influence the distribution of enteroendocrine cells in the rat intestine.Experientia · 1996Article
- Genetic engineering of carbohydrate biosynthetic pathways in transgenic mice demonstrates cell cycle-associated regulation of glycoconjugate production in small intestinal epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- A 20-nucleotide element in the intestinal fatty acid binding protein gene modulates its cell lineage-specific, differentiation-dependent, and cephalocaudal patterns of expression in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gastrointestinal tract is lined with a monolayer of cells that undergo perpetual and rapid renewal. Four principal, terminally differentiated cell types populate the monolayer, enterocytes, goblet cells, Paneth cells, and enteroendocrine cells. This epithelium exhibits complex patterns of regional differentiation, both from crypt-to-villus and from duodenum-to-colon. The "liver" fatty acid binding protein (L-FABP) gene represents a useful model for analyzing the molecular basis for intestinal epithelial differentiation since it exhibits cell-specific, region-specific, as well as developmental stage specific expression. We have previously linked portions of the 5' nontranscribed domain of the rat L-FABP gene to the human growth hormone (hGH) gene and analyzed expression of the fusion gene in adult transgenic mice. High levels of hGH expression were noted in enterocytes as well as cells that histologically resembled enteroendocrine cells. In the present study, we have used immunocytochemical techniques to map the distribution of enteroendocrine cells in the normal adult mouse gut and to characterize those that synthesize L-FABP. In addition, L-FABP/hGH fusion genes were used to identify subsets of enteroendocrine cells based on their ability to support hGH synthesis in several different pedigrees of transgenic mice. The results reveal remarkable differences in transgene expression between, and within, enteroendocrine cell populations previously classified only on the basis of their neuroendocrine products. In some cases, these differences are related to the position occupied by cells along the duodenal-to-colonic and crypt-to-villus axes of the gut. Thus, transgenes appear to be sensitive tools for examining the cellular and regional differentiation of this class of intestinal epithelial cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.