Trial reportCaries research2011
Biomimetic approach for root caries prevention using a proanthocyanidin-rich agent.
Trial report in Caries research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- Saturated anacardic acid preserves root dentin collagen under cariogenic challenge.Clinical oral investigations · 2026Article
- Evaluation of the remineralisation effect and biocompatibility of boron-doped bioactive glass material on artificial root surface caries.BMC oral health · 2025Article
- Formulation of Tooth Mousse Containing Grape Seed Extract and Comparative Evaluation of Its Remineralizing Effect with GC Tooth Mousse: AnInternational journal of clinical pediatric dentistry · 2025Article
- Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.Clinical oral investigations · 2024Article
- Evaluation of the efficacy of various remineralization agents and grape seed extract on microhardness and lesion depth of primary tooth enamel: An in vitro study.Journal of dental research, dental clinics, dental prospects · 2024Article
- Dentinomimetics and cementomimetics of Moringa oleifera leaves extract.Scientific reports · 2023Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Evaluation of Proanthocyanidin-based dentifrices on dentin-wear after erosion and dental abrasion -Journal of clinical and experimental dentistry · 2022Article
- The effect of proanthocyanidin and casein phosphopeptide-amorphous calcium phosphate on the bond strength durability to caries-affected dentin.Clinical and experimental dental research · 2021Article
- Salivary Pellicle Modification with Grape-seed Extract: In Vitro Study on the Effect on Bacterial Adhesion and Biofilm Formation.Oral health & preventive dentistry · 2021Article
- Research Advances in the Use of Bioactive Compounds fromAntioxidants (Basel, Switzerland) · 2020Review
- Effect of Silver Diamine Fluoride and Proanthocyanidin on Mechanical Properties of Caries-Affected Dentin.European journal of dentistry · 2019Article
- UVA-activated riboflavin promotes collagen crosslinking to prevent root caries.Scientific reports · 2019Article
- Effect of Proanthocyanidin, Fluoride and Casein Phosphopeptide Amorphous Calcium Phosphate Remineralizing Agents on Microhardness of Demineralized Dentin.Journal of dentistry (Tehran, Iran) · 2017Article
- [Effect of Pinus massoniana needle extract on root dentin demineralization in vitro].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Article
- Dentin biomodification potential depends on polyphenol source.Journal of dental research · 2014Article
- Dentin biomodification: strategies, renewable resources and clinical applications.Dental materials : official publication of the Academy of Dental Materials · 2014Review
- Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration.Frontiers in physiology · 2013Review
- Site specific properties of carious dentin matrices biomodified with collagen cross-linkers.American journal of dentistry · 2013Article
- Effect of Bioactive Primers on Bacterial-Induced Secondary Caries at the Tooth-Resin Interface.Operative dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The aim of this study was to evaluate the effects of a proanthocyanidin-rich grape seed extract (GSE) on the in vitro demineralization of root dentine. Root fragments were obtained from sound human teeth. The fragments were randomly assigned to different treatments solutions: GSE, fluoride (F), GSE+F and distilled water (control). Samples were treated daily for 30 min and subjected to a pH cycling artificial caries protocol using demineralization cycles (2.2 mM CaCl(2)×H(2)O, 2.2 mM KH(2)PO(4), 50 mM acetic acid, pH 4.3) for 6 h and remineralization cycles (20 mM HEPES, 2.25 mM CaCl(2)×H(2)O, 1.35 mM KH(2)PO(4), 130 mM KCl, pH 7.0) for 17.5 h. Mineral loss (ΔZ) and lesion depth (LD) were determined after 18 days of treatment/pH cycling, by transverse microradiography. GSE was able to minimize ΔZ and LD compared with the control group (p < 0.0001). The GSE+F and F groups showed the lowest values of ΔZ and LD (p < 0.05), with no statistically significant differences between them (p = 0.554 and p = 0.726, respectively). A biomimetic approach to strengthen root dentine using GSE results in decreased rates of root demineralization and may be used in conjunction with F to prevent root caries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.