ArticleJournal of innate immunity2012
Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections.
Article in Journal of innate immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Interplay between group AMicrobiology and molecular biology reviews : MMBR · 2024Review
- HIF-α Activation Impacts Macrophage Function during MurinePathogens (Basel, Switzerland) · 2021Article
- Evaluation of IL-17D in Host Immunity to Group AJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Crucial Role of Nucleic Acid Sensing via Endosomal Toll-Like Receptors for the Defense ofFrontiers in immunology · 2019Article
- Group AMicrobiology spectrum · 2019Article
- Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group AProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis.The Journal of infectious diseases · 2018Article
- Group A Streptococcus encounters with host macrophages.Future microbiology · 2018Review
- Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection.PLoS pathogens · 2017Article
- Inflammasome/IL-1β Responses to Streptococcal Pathogens.Frontiers in immunology · 2015Review
- Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.PloS one · 2015Article
- Host responses to group a streptococcus: cell death and inflammation.PLoS pathogens · 2014Review
- Responses of innate immune cells to group A Streptococcus.Frontiers in cellular and infection microbiology · 2014Review
- Subterfuge and sabotage: evasion of host innate defenses by invasive gram-positive bacterial pathogens.Annual review of microbiology · 2014Review
- Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity.Infection and immunity · 2014Article
- A farewell to arms: streptococcal strategies to cope with innate immunity.Journal of innate immunity · 2014Article
- Positive regulation of TRAF6-dependent innate immune responses by protein phosphatase PP1-γ.PloS one · 2014Article
- Recognition of pathogen-associated nucleic acids by endosomal nucleic acid-sensing toll-like receptors.Acta biochimica et biophysica Sinica · 2013Review
- Cofactors required for TLR7- and TLR9-dependent innate immune responses.Cell host & microbe · 2012Article
- DNase Sda1 allows invasive M1T1 Group A Streptococcus to prevent TLR9-dependent recognition.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.