Evidence map›Paper›PMID 21860079›Full record

ArticlePhysics in medicine and biology2011

Computerized three-class classification of MRI-based prognostic markers for breast cancer.

Neha Bhooshan, Maryellen Giger, Darrin Edwards, Yading Yuan, Sanaz Jansen, Hui Li, Li Lan, Husain Sattar, Gillian Newstead

Abstract readEvaluation Study
In one paragraph

Article in Physics in medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Sureness of classification of breast cancers as pure ductal carcinomaJournal of medical imaging (Bellingham, Wash.) · 2025
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  7. Radiogenomics of breast cancer using dynamic contrast enhanced MRI and gene expression profiling.Cancer imaging : the official publication of the International Cancer Imaging Society · 2019
    Article
  8. Article
  9. Most-enhancing tumor volume by MRI radiomics predicts recurrence-free survival "early on" in neoadjuvant treatment of breast cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2018
    Article
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  12. Article
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  18. Review
  19. Article
  20. Quantitative ultrasound image analysis of axillary lymph node status in breast cancer patients.International journal of computer assisted radiology and surgery · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neha BhooshanDepartment of Radiology, The University of Chicago, Chicago, IL 60637, USA. bhooshan@uchicago.edu
Maryellen Giger
Darrin Edwards
Yading Yuan
Sanaz Jansen
Hui Li
Li Lan
Husain Sattar
Gillian Newstead

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI THOMAS F GAJEWSKI · 1985 to 2026
$122.1M
Variation in Hormone and xenobiotic metabolizing enzyme genes and breast cancerP50CA125183 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2006 to 2010
$11.3M
Optimization of CAD Output in Breast ImagingR21CA113800 · NCI · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN L. · 2006 to 2007
$316k
High-Performance Computer Cluster for Image AnalysisS10RR021039 · NCRR · UNIVERSITY OF CHICAGO · PI NISHIKAWA, ROBERT M · 2007 to 2007
$230k
NCI NIH HHS P30 CA014599NCI NIH HHS P30 CA14599NCI NIH HHS P50 CA125183NCI NIH HHS P50-CA125183NCI NIH HHS R21 CA113800NCRR NIH HHS S10 RR021039
6 · The paper itself

Abstract

The purpose of this study is to investigate whether computerized analysis using three-class Bayesian artificial neural network (BANN) feature selection and classification can characterize tumor grades (grade 1, grade 2 and grade 3) of breast lesions for prognostic classification on DCE-MRI. A database of 26 IDC grade 1 lesions, 86 IDC grade 2 lesions and 58 IDC grade 3 lesions was collected. The computer automatically segmented the lesions, and kinetic and morphological lesion features were automatically extracted. The discrimination tasks-grade 1 versus grade 3, grade 2 versus grade 3, and grade 1 versus grade 2 lesions-were investigated. Step-wise feature selection was conducted by three-class BANNs. Classification was performed with three-class BANNs using leave-one-lesion-out cross-validation to yield computer-estimated probabilities of being grade 3 lesion, grade 2 lesion and grade 1 lesion. Two-class ROC analysis was used to evaluate the performances. We achieved AUC values of 0.80 ± 0.05, 0.78 ± 0.05 and 0.62 ± 0.05 for grade 1 versus grade 3, grade 1 versus grade 2, and grade 2 versus grade 3, respectively. This study shows the potential for (1) applying three-class BANN feature selection and classification to CADx and (2) expanding the role of DCE-MRI CADx from diagnostic to prognostic classification in distinguishing tumor grades.

Indexed as

Breast NeoplasmsFemaleHumansMagnetic Resonance ImagingNeoplasm GradingPattern Recognition, AutomatedRadiographic Image Interpretation, Computer-AssistedRadionuclide ImagingROC Curve

Identifiers

PMID21860079
PMCPMC4134441

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.