Evidence map›Paper›PMID 21860048›Full record

Trial reportSchizophrenia bulletin2011

Compensatory cognitive training for psychosis: who benefits? Who stays in treatment?

Elizabeth W Twamley, Cynthia Z Burton, Lea Vella

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04551027 (Assessing the Effect of Compensatory Cognitive Intervention for Functional Capacity, Cognitive Functions and Severity of Symptoms Among People With Severe Mental Illness), which is not on this map. Cited by 42 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04551027 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Assessing the Effect of Compensatory Cognitive Intervention for Functional Capacity, Cognitive Functions and Severity of Symptoms Among People With Severe Mental Illness

TypeinterventionalSponsorShalvata Mental Health CenterRan2020 to 2021Enrolled60ConditionsMood Disorders, Schizophrenia, Schizoaffective DisorderArmscompensatory cognitive treatment
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  9. Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.The British journal of psychiatry : the journal of mental science · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Elizabeth W TwamleyDepartment of Psychiatry, University of California, San Diego, 140 Arbor Drive, San Diego, CA 92103, USA. etwamley@ucsd.edu
Cynthia Z Burton
Lea Vella

Funding

Cognitive Training to Improve Work Outcomes in Severe Mental IllnessR01MH080150 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TWAMLEY, ELIZABETH W · 2008 to 2012
$1.4M
NIMH NIH HHS R01 MH080150
6 · The paper itself

Abstract

Enhancing cognitive performance to improve functioning in schizophrenia is a fundamental research priority. Previous investigations have demonstrated that various types of cognitive training (CT) can improve neuropsychological performance, psychosocial functioning, and psychiatric symptom severity. However, there is limited information about individual differences that may predict CT response and adherence to treatment. The purpose of this study was to identify who is likely to drop out of this type of study as well as this type of intervention and to explore individual factors predicting treatment outcome. Participants included 89 outpatients diagnosed with a primary psychotic disorder who enrolled in a randomized controlled trial of compensatory CT and were assessed at baseline, 3 months (posttest), and 6 months (follow-up). Study completers had more formal education and lower daily doses of antipsychotic medications than did dropouts with no CT exposure, but the groups did not otherwise differ. There were no significant differences between participants who completed CT and those who began CT but later dropped out. CT-associated improvement was correlated with worse baseline scores on measures of cognitive performance, symptom severity, functional capacity, and self-rated quality of life, cognitive problems, and strategy use. These results suggest that those with lower baseline functioning may have more room to improve following CT. The pattern of correlations in this sample indicated that many types of individuals can improve with CT treatment, including older patients.

Indexed as

Schizophrenic PsychologyAdultAgedCognitive Behavioral TherapyCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPsychiatric Status Rating ScalesPsychotic DisordersSeverity of Illness IndexTreatment OutcomeYoung Adult

Identifiers

PMID21860048
PMCPMC3160125

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.