Trial reportSchizophrenia bulletin2011
Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosis.
Trial report in Schizophrenia bulletin, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 7 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Network Meta-Analysis Indicates Superior Effects of Omega-3 Polyunsaturated Fatty Acids in Preventing the Transition to Psychosis in Individuals at Clinical High-Risk.The international journal of neuropsychopharmacology · 2024Pooled it
- Transition to psychosis in randomized clinical trials of individuals at clinical high risk of psychosis compared to observational cohorts: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2021Pooled it
- Cannabis use in individuals at clinical high-risk for psychosis: a comprehensive review.Social psychiatry and psychiatric epidemiology · 2020Pooled it
- Interventions for prodromal stage of psychosis.The Cochrane database of systematic reviews · 2019Pooled it
- Comorbid Personality Disorders in Individuals With an At-Risk Mental State for Psychosis: A Meta-Analytic Review.Frontiers in psychiatry · 2019Pooled it
- Cannabis use and symptom severity in individuals at ultra high risk for psychosis: a meta-analysis.Acta psychiatrica Scandinavica · 2017Pooled it
- A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia.Journal of psychiatry & neuroscience : JPNPooled it
- The Staging Model in Psychosis and Preventive Interventions: An Emerging Field With Debates on Conceptual Models and Interpretation of the Evidence Base.Early intervention in psychiatry · 2026Review
- Bridging the phenomenological gap between predictive basic-symptoms and attenuated positive symptoms: a cross-sectional network analysis.Schizophrenia (Heidelberg, Germany) · 2022Article
- Overoptimistic Literature and Methodological Biases Favoring Cognitive Behavioral Therapy for the Prevention of Psychosis.Schizophrenia bulletin · 2022Article
- Commentary. Toward a core outcomes assessment set for clinical high risk.Schizophrenia research · 2021Article
- Altering the course of schizophrenia: progress and perspectives.Nature reviews. Drug discovery · 2016Review
- Animal Models of Maternal Immune Activation in Depression Research.Current neuropharmacology · 2016Review
- [Should antipsychotics be used in prodromal stages of schizophrenia to prevent psychosis? Con].Der Nervenarzt · 2015Article
- Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation.Schizophrenia bulletin · 2015Review
- [Services for the early recognition of psychoses and bipolar disorders in Germany: inventory survey study].Der Nervenarzt · 2015Article
- Evidence-based psychotherapy for the prevention and treatment of first-episode psychosis.European archives of psychiatry and clinical neuroscience · 2014Review
- Prediction and prevention of psychosis: current progress and future tasks.European archives of psychiatry and clinical neuroscience · 2014Article
- [Prediction of psychoses].Der Nervenarzt · 2014Review
- The usefulness for indicated prevention of severe mental disorders should play a central part in the further development of CBT.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antipsychotics, cognitive behavioral therapy (CBT), and omega-3-fatty acids have been found superior to control conditions as regards prevention of psychosis in people at-risk of first-episode psychosis. However, no large-scale trial evaluating the differential efficacy of CBT and antipsychotics has been performed yet. In PREVENT, we evaluate CBT, aripiprazole, and clinical management (CM) as well as placebo and CM for the prevention of psychosis in a randomized, double-blind, placebo-controlled trial with regard to the antipsychotic intervention and a randomized controlled trial with regard to the CBT intervention with blinded ratings. The hypotheses are first that CBT and aripiprazole and CM are superior to placebo and CM and second that CBT is not inferior to aripiprazole and CM combined. The primary outcome is transition to psychosis. By November 2010, 156 patients were recruited into the trial. The subjects were substantially functionally compromised (Social and Occupational Functioning Assessment Scale mean score 52.5) and 78.3% presented with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition axis I comorbid diagnosis. Prior to randomization, 51.5% of the participants preferred to be randomized into the CBT arm, whereas only 12.9% preferred pharmacological treatment. First, assessments of audiotaped treatment sessions confirmed the application of CBT-specific skills in the CBT condition and the absence of those in CM. The overall quality rating of the CBT techniques applied in the CBT condition was good. When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.