ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Age-associated alteration in innate immune response in captive baboons.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 32 citations in OpenAlex.
- Effects of Lifelong Low Social Status on Inflammatory Markers in Adult Female Macaques.Biomolecules · 2026Article
- Roles of cytokines in modulatingFrontiers in parasitology · 2025Article
- Insights into pathophysiology and therapeutic strategies for heat stroke: Lessons from a baboon model.Experimental physiology · 2024Review
- Age-associated alterations in immune and inflammatory responses in captive olive baboons (Frontiers in aging · 2024Article
- Immunosenescence and inflammaging in the aged horse.Immunity & ageing : I & A · 2023Review
- Effects of Modified Electroconvulsive Therapy on Serum Cortisol, Nesfatin-1, and Pro-inflammatory Cytokine Levels in Elderly Patients With Treatment-Resistant Depression.Frontiers in endocrinology · 2022Article
- Nonhuman primate models for SARS-CoV-2 research: Consider alternatives to macaques.Lab animal · 2021Article
- Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Comparative medicine · 2021Article
- Optimization of culture conditions for the derivation and propagation of baboon (Papio anubis) induced pluripotent stem cells.PloS one · 2018Article
- DNA nanoparticles are safe and nontoxic in non-human primate eyes.International journal of nanomedicine · 2018Article
- Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells.Stem cells translational medicine · 2016Article
- Age-Associated Increase in Cytokine Production During Systemic Inflammation-II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- The effects of age and cytomegalovirus on markers of inflammation and lymphocyte populations in captive baboons.PloS one · 2014Article
- Serum IL-17, IL-23, and TGF-β levels in type 1 and type 2 diabetic patients and age-matched healthy controls.BioMed research international · 2014Article
- Age- and gender-associated changes in the concentrations of serum TGF-1β, DHEA-S and IGF-1 in healthy captive baboons (Papio hamadryas anubis).General and comparative endocrinology · 2014Article
- Aging-induced dysregulation of dicer1-dependent microRNA expression impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells.The journals of gerontology. Series A, Biological sciences and medical sciences · 2013Article
- The effect of season on inflammatory response in captive baboons.Journal of medical primatology · 2012Article
- Testing the oxidative stress hypothesis of aging in primate fibroblasts: is there a correlation between species longevity and cellular ROS production?The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Baboons are an ideal model for studies of human inflammatory response due to their physiological and immunological similarities to people; however; little is known about how age affects immune function in the baboon. We sought to determine if baboons show age-related innate immune changes similar to that described in people. Age was correlated with increased serum C-reactive protein and interleukin-6 or, however, no change in interleukin-10 concentration was observed (n = 120 baboons). Cytokine release from unstimulated peripheral blood mononuclear cells as well as following immune (lipopolysaccharide) stimulation increased with age. When whole blood was assayed, both lipopolysaccharide stimulated and unstimulated samples showed an age-related increase in interleukin-6 response, although the unstimulated cytokine response was reduced compared with that observed in peripheral blood mononuclear cells. Tumor necrosis factor-α response was not related to age. Cytokine response in lipopolysaccharide-stimulated whole blood was negatively correlated with serum DHEA-S concentration and positively correlated with TGF-β concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.