ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Telomere dynamics in rhesus monkeys: no apparent effect of caloric restriction.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Calorie restriction modulates the transcription of genes related to stress response and longevity in human muscle: The CALERIE study.Aging cell · 2023Trial
- Comparative lifespan and healthspan of nonhuman primate species common to biomedical research.GeroScience · 2025Article
- Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging.Biology · 2021Review
- No sex differences in adult telomere length across vertebrates: a meta-analysis.Royal Society open science · 2020Article
- Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length.Scientific reports · 2019Article
- Fasting and Its Impact on Skin Anatomy, Physiology, and Physiopathology: A Comprehensive Review of the Literature.Nutrients · 2019Review
- Shaping long-term primate development: Telomere length trajectory as an indicator of early maternal maltreatment and predictor of future physiologic regulation.Development and psychopathology · 2017Article
- Caloric restriction delays age-related methylation drift.Nature communications · 2017Article
- Sex differences in leucocyte telomere length in a free-living mammal.Molecular ecology · 2017Article
- Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.Nutrition and healthy aging · 2017Article
- Cumulative stress in research animals: Telomere attrition as a biomarker in a welfare context?BioEssays : news and reviews in molecular, cellular and developmental biology · 2016Review
- Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage.Longevity & healthspan · 2013Article
- The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women.PloS one · 2013Article
- Telomeres shorten at equivalent rates in somatic tissues of adults.Nature communications · 2013Article
- Divergence of sperm and leukocyte age-dependent telomere dynamics: implications for male-driven evolution of telomere length in humans.Molecular human reproduction · 2012Article
- Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Growth hormone and IGF-1 deficiency exacerbate high-fat diet-induced endothelial impairment in obese Lewis dwarf rats: implications for vascular aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
The role of telomere attrition in limiting the replicative capacity of cells in culture is well established. In humans, epidemiologic evidence suggests telomere length (TL) in leukocytes is highly variable at birth and inversely related to age. Although calorie restriction (CR) significantly increases life span in most rodent models, its association with TL is unknown. Using linear regression analysis, TLs (as measured by Southern blot analysis) of skeletal muscle (a postmitotic tissue that largely represents early development TL), fat, leukocytes, and skin were tested for effects of age, sex, and diet in 48 control and 23 calorie restriction rhesus monkeys. After controlling for the individual's muscle mean TL, differences between leukocytes muscle and skin muscle were significantly associated with age (p = .002; p = .002) and sex (p = .003; p = .042), but not calorie restriction (p = .884; p = .766). Despite an age-dependent shortening of TL in leukocytes and skin, calorie restriction did not significantly affect TL dynamics in these samples.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.