Evidence map›Paper›PMID 21859944›Full record

ArticleAntimicrobial agents and chemotherapy2011

Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France.

Elodie Blanchard, Olivier Lortholary, Karine Boukris-Sitbon, Marie Desnos-Ollivier, Françoise Dromer, Didier Guillemot, French Mycosis Study Group

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Recurrent episodes of Candidemia due toMedical mycology case reports · 2016
    Article
  11. Article
  12. Article
  13. Article
  14. Mechanisms of echinocandin antifungal drug resistance.Annals of the New York Academy of Sciences · 2015
    Review
  15. Update on Antifungal Drug Resistance.Current clinical microbiology reports · 2015
    Article
  16. Epidemiology of echinocandin resistance inCurrent fungal infection reports · 2014
    Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elodie BlanchardINSERM U 657, Paris, France.
Olivier Lortholary
Karine Boukris-Sitbon
Marie Desnos-Ollivier
Françoise Dromer
Didier Guillemot
French Mycosis Study Group
Centre National de la Recherche Scientifique · FRInstitut Pasteur · FRUniversité de Versailles Saint-Quentin-en-Yvelines · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68-16.35) and with an age of ≤ 65 years (OR = 3.27; 95% CI, 1.26-8.50).

Indexed as

AgedAntifungal AgentsCandidaCase-Control StudiesCaspofunginDrug Resistance, FungalEchinocandinsFemaleFranceFungemiaHematologic NeoplasmsHumansLipopeptidesMaleMiddle AgedRisk FactorsAntifungal AgentsCaspofunginEchinocandinsLipopeptides

Identifiers

PMID21859944
PMCPMC3194997
OpenAlexW2129716113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.