Evidence map›Paper›PMID 21859943›Full record

ArticleAntimicrobial agents and chemotherapy2011

Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.

Wei Li, Rama M Sakamuri, Danielle E Lyons, Florenda M Orcullo, Vidyagouri Shinde, Edred Lao Dela Pena, Armi A Maghanoy, Irene B Mallari, Esterlina V Tan, Indira Nath and 3 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mycobacterium leprae in Colombia described by SNP7614 in gyrA, two minisatellites and geography.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Wei LiDepartment of Microbiology, Colorado State University, Fort Collins, Colorado 80523, USA.
Rama M Sakamuri
Danielle E Lyons
Florenda M Orcullo
Vidyagouri Shinde
Edred Lao Dela Pena
Armi A Maghanoy
Irene B Mallari
Esterlina V Tan
Indira Nath
Patrick J Brennan
Marivic Balagon
Varalakshmi Vissa
University of Cebu · PHColorado State University · USLepra Society · IN

Funding

Molecular Epidemiology of LeprosyR01AI063457 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI VISSA, VARALAKSHMI D · 2005 to 2010
$1.9M
Leprosy Research Support-Post Genome -26625469N01AI025469 · NIAID · Colorado State University · 2004 to 2004
–
NIAID NIH HHS AI-063457NIAID NIH HHS N01 AI025469NIAID NIH HHS N01-AI-25469NIAID NIH HHS R01 AI063457
6 · The paper itself

Abstract

Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB. These findings indicate that dapsone resistance is being transmitted.

Indexed as

Bacterial ProteinsDapsoneHumansIndiaLeprostatic AgentsLeprosyMolecular EpidemiologyMutationMycobacterium lepraePhilippinesRifampinBacterial ProteinsDapsoneLeprostatic AgentsRifampin

Identifiers

PMID21859943
PMCPMC3195063
OpenAlexW2103927741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.