ArticleAntimicrobial agents and chemotherapy2011
ArmA methyltransferase in a monophasic Salmonella enterica isolate from food.
Article in Antimicrobial agents and chemotherapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 30 citations in OpenAlex.
- Antibiotic: a boon to mankind and doom to the environment - an insight on biological and non-biological degradation processes.Frontiers in microbiology · 2026Review
- Ribosome-targeting antibiotics and resistanceRSC medicinal chemistry · 2023Review
- Antimicrobial resistance and One Health.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2022Review
- pCTX-M3-Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range.International journal of molecular sciences · 2021Review
- Isolation, Antimicrobial Resistance Phenotypes, and Virulence Genes ofFrontiers in veterinary science · 2021Article
- Extensive antimicrobial resistance mobilization via multicopy plasmid encapsidation mediated by temperate phages.The Journal of antimicrobial chemotherapy · 2020Article
- Sequence-based epidemiology of an OXA-48 plasmid during a hospital outbreak.Antimicrobial agents and chemotherapy · 2019Article
- Aminoglycoside Resistance: The Emergence of Acquired 16S Ribosomal RNA Methyltransferases.Infectious disease clinics of North America · 2016Review
- Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.MedChemComm · 2016Article
- Positive epistasis between co-infecting plasmids promotes plasmid survival in bacterial populations.The ISME journal · 2014Article
- Antibiotic resistance genes in the bacteriophage DNA fraction of human fecal samples.Antimicrobial agents and chemotherapy · 2014Article
- Klebsiella pneumoniae sequence type 11 from companion animals bearing ArmA methyltransferase, DHA-1 β-lactamase, and QnrB4.Antimicrobial agents and chemotherapy · 2013Article
- Association of extended-spectrum β-lactamase VEB-5 and 16S rRNA methyltransferase armA in Salmonella enterica from the United Kingdom.Antimicrobial agents and chemotherapy · 2012Article
- Fitness cost and interference of Arm/Rmt aminoglycoside resistance with the RsmF housekeeping methyltransferases.Antimicrobial agents and chemotherapy · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We report here the identification and characterization of a multidrug-resistant Salmonella enterica subspecies I.4,12:i:- isolate recovered from chicken meat sampled in a supermarket on February 2009 in La Reunion, a French island in the Indian Ocean. Susceptibility testing showed an unusually high-level resistance to gentamicin, as well as to ampicillin, expanded-spectrum cephalosporins and amoxicillin-clavulanate. Molecular analysis of the 16S rRNA methyltransferases revealed presence of the armA gene, together with bla(TEM-1), bla(CMY-2), and bla(CTX-M-3). All of these genes could be transferred en bloc through conjugation into Escherichia coli at a frequency of 10(-5) CFU/donor. Replicon typing and S1 pulsed-field gel electrophoresis revealed that the armA gene was borne on an ~150-kb broad-host-range IncP plasmid, pB1010. To elucidate how armA had integrated in pB1010, a PCR mapping strategy was developed for Tn1548, the genetic platform for armA. The gene was embedded in a Tn1548-like structure, albeit with a deletion of the macrolide resistance genes, and an IS26 was inserted within the mel gene. To our knowledge, this is the first report of ArmA methyltransferase in food, showing a novel route of transmission for this resistance determinant. Further surveillance in food-borne bacteria will be crucial to determine the role of food in the spread of 16S rRNA methyltransferase genes worldwide.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.