ArticleInfection and immunity2011
The iron-responsive Fur/RyhB regulatory cascade modulates the Shigella outer membrane protease IcsP.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- A Tale aboutMicroorganisms · 2023Review
- Toward aInternational journal of molecular sciences · 2023Review
- Shigella Outer Membrane Vesicles as Promising Targets for Vaccination.International journal of molecular sciences · 2022Review
- Insights into transcriptional silencing and anti-silencing in Shigella flexneri: a detailed molecular analysis of the icsP virulence locus.Molecular microbiology · 2018Article
- RNA-based mechanisms of virulence control in Enterobacteriaceae.RNA biology · 2017Review
- Article
- Riboregulators: Fine-Tuning Virulence in Shigella.Frontiers in cellular and infection microbiology · 2016Review
- The small RNA RyhB contributes to siderophore production and virulence of uropathogenic Escherichia coli.Infection and immunity · 2014Article
- Functional genomics of Lactobacillus casei establishment in the gut.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The iron stimulon and fur regulon of Geobacter sulfurreducens and their role in energy metabolism.Applied and environmental microbiology · 2014Article
- Iron-responsive bacterial small RNAs: variations on a theme.Metallomics : integrated biometal science · 2013Review
- Ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzae.Infection and immunity · 2013Article
- VirF-independent regulation of Shigella virB transcription is mediated by the small RNA RyhB.PloS one · 2012Article
- Elemental economy: microbial strategies for optimizing growth in the face of nutrient limitation.Advances in microbial physiology · 2012Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Actin-based motility is central to the pathogenicity of the intracellular bacterial pathogen Shigella. Two Shigella outer membrane proteins, IcsA and IcsP, are required for efficient actin-based motility in the host cell cytoplasm, and the genes encoding both proteins are carried on the large virulence plasmid. IcsA triggers actin polymerization on the surface of the bacterium, leading to the formation of an actin tail that allows both intra- and intercellular spread. IcsP, an outer membrane protease, modulates the amount and distribution of the IcsA protein on the bacterial surface through proteolytic cleavage of IcsA. Transcription of icsP is increased in the presence of VirB, a DNA-binding protein that positively regulates many genes carried on the large virulence plasmid. In Shigella dysenteriae, the small regulatory RNA RyhB, which is a member of the iron-responsive Fur regulon, suppresses several virulence-associated phenotypes by downregulating levels of virB in response to iron limitation. Here we show that the Fur/RyhB regulatory pathway downregulates IcsP levels in response to low iron concentrations in Shigella flexneri and that this occurs at the level of transcription through the RyhB-dependent regulation of VirB. These observations demonstrate that in Shigella species the Fur/RyhB regulatory pathway provides a mechanism to finely tune the expression of icsP in response to the low concentrations of free iron predicted to be encountered within colonic epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.