ArticleThe Journal of physiology2011
Purinergic signalling mobilizes mitochondrial Ca²⁺ in mouse Sertoli cells.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Cell type-specific Ca2+ signals govern mouse seminiferous tubule physiology.PLoS biology · 2026Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Kir7.1 is the physiological target for hormones and steroids that regulate uteroplacental function.Science advances · 2025Article
- Article
- A revised conceptual framework for mouse vomeronasal pumping and stimulus sampling.Current biology : CB · 2024Article
- Purinergic Signaling in Spermatogenesis.Frontiers in endocrinology · 2022Review
- Purinergic signaling in the male reproductive tract.Frontiers in endocrinology · 2022Review
- Article
- Synchronous Infra-Slow Oscillations Organize Ensembles of Accessory Olfactory Bulb Projection Neurons into Distinct Microcircuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Signal Detection and Coding in the Accessory Olfactory System.Chemical senses · 2018Review
- ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.Scientific reports · 2018Article
- Article
- The P2YFrontiers in pharmacology · 2018Article
- Glycolysis and oxidative phosphorylation are essential for purinergic receptor-mediated angiogenic responses in vasa vasorum endothelial cells.American journal of physiology. Cell physiology · 2017Article
- In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ.Journal of visualized experiments : JoVE · 2016Article
- Distinct purinergic signaling pathways in prepubescent mouse spermatogonia.The Journal of general physiology · 2016Article
- Interdependent Conductances Drive Infraslow Intrinsic Rhythmogenesis in a Subset of Accessory Olfactory Bulb Projection Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- GAR22β regulates cell migration, sperm motility, and axoneme structure.Molecular biology of the cell · 2016Article
- Purinergic signaling pathways in endocrine system.Autonomic neuroscience : basic & clinical · 2015Review
- Extracellular pH regulates excitability of vomeronasal sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intimate bidirectional communication between Sertoli cells and developing germ cells ensures the integrity and efficiency of spermatogenesis. Yet, a conceptual mechanistic understanding of the physiological principles that underlie Sertoli cell autocrine and paracrine signalling is lacking. Here, we characterize a purinergic Ca(2+) signalling network in immature mouse Sertoli cells that consists of both P2X2 and P2Y2 purinoceptor subtypes, the endoplasmic reticulum and, notably, mitochondria. By combining a transgenic mouse model with a dedicated bioluminescence imaging device, we describe a novel method to monitor mitochondrial Ca(2+) mobilization in Sertoli cells at subcellular spatial and millisecond temporal resolution. Our data identify mitochondria as essential components of the Sertoli cell signalling 'toolkit' that control the shape of purinergic Ca(2+) responses, and probably several other paracrine Ca(2+)-dependent signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.