ArticleThe Journal of physiology2011
Cannabinoids attenuate hippocampal γ oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- Inhibition of fatty acid amide hydrolase reverses aberrant prefrontal gamma oscillations in the sub-chronic PCP model for schizophrenia.Experimental brain research · 2024Article
- Dialectics of perisomatic inhibition-The unity and conflict of opposites.Frontiers in neural circuits · 2024Review
- Perinatal Fentanyl Exposure Leads to Long-Lasting Impairments in Somatosensory Circuit Function and Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Nightmares and the Cannabinoids.Current neuropharmacology · 2020Review
- Effects of Adolescent THC Exposure on the Prefrontal GABAergic System: Implications for Schizophrenia-Related Psychopathology.Frontiers in psychiatry · 2018Review
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Adolescent THC Exposure Causes Enduring Prefrontal Cortical Disruption of GABAergic Inhibition and Dysregulation of Sub-Cortical Dopamine Function.Scientific reports · 2017Article
- Neurophysiology of space travel: energetic solar particles cause cell type-specific plasticity of neurotransmission.Brain structure & function · 2017Article
- Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with ΔAddiction biology · 2017Article
- Development of sensory gamma oscillations and cross-frequency coupling from childhood to early adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy.Nature reviews. Neuroscience · 2015Review
- Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.Neuropharmacology · 2014Article
- Extracellular calcium controls the expression of two different forms of ripple-like hippocampal oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Muscarinic cholinergic receptors modulate inhibitory synaptic rhythms in hippocampus and neocortex.Frontiers in synaptic neuroscience · 2014Review
- Optogenetic identification of an intrinsic cholinergically driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1.The Journal of physiology · 2014Article
- Article
- Adolescent cannabinoid exposure permanently suppresses cortical oscillations in adult mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Modulation by pregnenolone sulfate of filtering properties in the hippocampal trisynaptic circuit.Hippocampus · 2012Article
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6 authors at 2 institutions in 1 country.
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Abstract
CB(1) cannabinoid receptor (CB(1)R) activation by exogenous ligands can impair memory processes, which critically depend on synchronous neuronal activities that are temporarily structured by oscillations. In this study, we aimed to reveal the mechanisms underlying the cannabinoid-induced decrease in gamma oscillations. We first verified that cannabinoids (CP55,940 and WIN55,212-2) readily suppressed carbachol-induced gamma oscillations in the CA3 region of hippocampal slices via activation of CB(1)Rs. The cannabinoid-induced decrease in the peak power of oscillations was accompanied by reduced and less precise firing activity in CA3 pyramidal cells and fast spiking basket cells. By examining the cannabinoid sensitivity of synaptic inputs we found that the amplitude of evoked excitatory postsynaptic currents was significantly suppressed upon CB(1)R activation in both CA3 pyramidal cells and fast spiking basket cells. In contrast, evoked inhibitory postsynaptic currents in CA3 pyramidal cells were unaltered. Furthermore, we observed that a CB(1)R agonist-induced decrease in the oscillation power at the beginning of the drug application was accompanied primarily by the reduced discharge of fast spiking basket cells, while pyramidal cell firing was unaltered. This result implies that the dampening of cholinergically induced gamma oscillations in the hippocampus by cannabinoids can be explained by a reduced excitatory input predominantly onto fast spiking basket cells, which leads to a reduction in neuronal firing frequency and precision, and thus to smaller field potentials. In addition, we uncovered that the spontaneously occurring sharp wave-ripple activities in hippocampal slices could also be suppressed by CB(1)R activation suggesting that cannabinoids profoundly reduce the intrinsically generated oscillatory activities at distinct frequencies in CA3 networks by reducing synaptic neurotransmission.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.