ArticleBiological research for nursing2013
Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.
Article in Biological research for nursing, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Renin angiotensinogen system gene polymorphisms and essential hypertension among people of West African descent: a systematic review.Journal of human hypertension · 2016Pooled it
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- A Splicing Mutation inInternational journal of molecular sciences · 2022Article
- African American mothers' attitudes towards genetic testing in the InterGEN study.Journal of community genetics · 2020Article
- Mouse models of SLC4-linked disorders of HCOAmerican journal of physiology. Cell physiology · 2018Review
- Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells.PloS one · 2018Article
- The combined effects of genetic risk and perceived discrimination on blood pressure among African Americans in the Jackson Heart Study.Medicine · 2017Article
- Genetics and genomic medicine in Mali: challenges and future perspectives.Molecular genetics & genomic medicine · 2016Article
- A Genome-wide study of blood pressure in African Americans accounting for gene-smoking interaction.Scientific reports · 2016Article
- Structure and Function of SLC4 Family [Formula: see text] Transporters.Frontiers in physiology · 2015Article
- Article
- Disturbed acid-base transport: an emerging cause of hypertension.Frontiers in physiology · 2013Review
- The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters.Physiological reviews · 2013Review
- Alternative methods for measuring obesity in African American women.The Yale journal of biology and medicine · 2013Article
- Blending genetics and sociocultural historical inquiry: ethics, culture, and human subjects protection in international cross cultural research.The Yale journal of biology and medicine · 2013Article
- Effects of parity on blood pressure among West African Dogon women.Ethnicity & disease · 2012Article
- Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women.Ethnicity & disease · 2012Article
- Genetic epidemiology of type 2 diabetes and cardiovascular diseases in Africa.Progress in cardiovascular diseasesReview
- The SLC4 family of bicarbonate (HCO₃⁻) transporters.Molecular aspects of medicineReview
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
The study of genetic polymorphisms and body mass index (BMI) among African women in Africa and in the United States contributes to our understanding of the genetic and environmental risk factors for hypertension. African American women have the highest prevalence of hypertension and obesity compared to other ethnic groups in the United States. Using a cross-sectional research design, we examined the effects of genetic and environmental risks of single nucleotide polymorphisms (SNPs) and BMI on blood pressure (BP) among three generations of West African Dogon women (N = 199). We genotyped six SNPs located in the candidate genes known to be related to hypertension. We tested the associations between these SNPs and systolic BP (SBP) and diastolic BP (DBP) with Fisher's exact tests, chi-square tests for independence, and multivariable linear mixed models. The SNP rs8179526 (SLC4A5) was significantly associated with SBP adjusted for age, age(2), and BMI (p = .02). The "C" allele variant of rs8179526 (allele frequency of 0.445) was associated with higher SBP. This SNP did not deviate from the Hardy-Weinberg equilibrium (HWE) with p value of .772. The SNP × BMI interaction effects associated with SBP and DBP were not significant. rs8179526 is located on the SLC4A5 gene on chromosome 2. SLC4A5 encodes a protein that transports sodium and bicarbonate across cell membranes while regulating cellular pH and contains several SNPs linked to elevated BP. Knowledge of the SNP's effect on hypertension among West African women can help health practitioners educate their patients about genetic risks of developing hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.