ArticleThe Journal of biological chemistry2011
Structural differences in lipomannans from pathogenic and nonpathogenic mycobacteria that impact CD1b-restricted T cell responses.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Drug-resistant strains ofFrontiers in cellular and infection microbiology · 2023Review
- The Bovine Tuberculoid Granuloma.Pathogens (Basel, Switzerland) · 2022Review
- Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.Critical reviews in immunology · 2021Article
- Disruption of the SucT acyltransferase inThe Journal of biological chemistry · 2019Article
- Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis.Pathogens and disease · 2018Review
- CD1 and mycobacterial lipids activate human T cells.Immunological reviews · 2015Review
- Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool.Immunological reviews · 2015Review
- Exposure of Monocytes to Lipoarabinomannan Promotes Their Differentiation into Functionally and Phenotypically Immature Macrophages.Journal of immunology research · 2015Article
- Role of Group 1 CD1-Restricted T Cells in Infectious Disease.Frontiers in immunology · 2015Review
- Macrophage immunoregulatory pathways in tuberculosis.Seminars in immunology · 2014Review
- Mannan core branching of lipo(arabino)mannan is required for mycobacterial virulence in the context of innate immunity.Cellular microbiology · 2013Article
- Macrophages in tuberculosis: friend or foe.Seminars in immunopathology · 2013Review
- Changes in the major cell envelope components of Mycobacterium tuberculosis during in vitro growth.Glycobiology · 2013Article
- Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting DNA damage and cytotoxicity in mouse macrophages.Antimicrobial agents and chemotherapy · 2013Article
- Galectin-3 regulates the innate immune response of human monocytes.The Journal of infectious diseases · 2013Article
- Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell differentiation.The Journal of biological chemistry · 2012Article
- Protection versus pathology in tuberculosis: recent insights.Current opinion in immunology · 2012Review
- Isolation of a distinct Mycobacterium tuberculosis mannose-capped lipoarabinomannan isoform responsible for recognition by CD1b-restricted T cells.Glycobiology · 2012Article
- Divergent effects of mycobacterial cell wall glycolipids on maturation and function of human monocyte-derived dendritic cells.PloS one · 2012Article
- Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Mannosylated molecules on the Mycobacterium tuberculosis surface are important determinants in the immunopathogenesis of tuberculosis. To date, much attention has been paid to mannose-capped lipoarabinomannan, which mediates phagocytosis and intracellular trafficking of M. tuberculosis by engaging the macrophage mannose receptor and subsequently binds to intracellular CD1b molecules for presentation to T cells. Another important mannosylated lipoglycan on the M. tuberculosis surface is lipomannan (LM). Comparative structural detail of the LMs from virulent and avirulent strains is limited as is knowledge regarding their differential capacity to be recognized by the adaptive immune response. Here, we purified LM from the avirulent M. smegmatis and the virulent M. tuberculosis H(37)R(v), performed a comparative structural biochemical analysis, and addressed their ability to stimulate CD1b-restricted T cell clones. We found that M. tuberculosis H(37)R(v) produces a large neutral LM (TB-LM); in contrast, M. smegmatis produces a smaller linear acidic LM (SmegLM) with a high succinate content. Correspondingly, TB-LM was not as efficiently presented to CD1b-restricted T cells as SmegLM. Thus, here we correlate the structure-function relationships for LMs with CD1b-restricted T cell responses and provide evidence that the structural features of TB-LM contribute to its diminished T cell responsiveness.
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Registered trials
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