ArticleRadiation research2011
Rapid loss of bone mass and strength in mice after abdominal irradiation.
Article in Radiation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture.BioMed research international · 2022Pooled it
- Tumor Radiotherapy-Induced Sympathetic Hyperactivation Orchestrates Rapid Systemic Bone Loss.Calcified tissue international · 2026Article
- Quantifying early pelvic radiation-induced bone injury with dual-energy CT: a rabbit model study of dynamic bone mineral and marrow adiposity changes.Frontiers in medicine · 2026Article
- Total body irradiation is associated with long-term deficits in femoral bone structure but not mechanical properties in male rhesus macaques.Scientific reports · 2024Article
- The effectiveness ofHeliyon · 2024Article
- Adipocyte- and Monocyte-Mediated Vicious Circle of Inflammation and Obesity (Review of Cellular and Molecular Mechanisms).International journal of molecular sciences · 2023 · on this mapReview
- Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Further Characterization of Multi-Organ DEARE and Protection by 16,16 Dimethyl Prostaglandin E2 in a Mouse Model of the Hematopoietic Acute Radiation Syndrome.Radiation research · 2023Article
- Effects of Radiotherapy Upon Bone Structure-Strength Relationships Vary With Sex and Fractionation of Dosing.The Iowa orthopaedic journal · 2023Article
- Persistent Abnormal Immunocytes Induced Systemic Bone Loss in Locally Irradiated Rats.Calcified tissue international · 2021Article
- Relations Between Bone Quantity, Microarchitecture, and Collagen Cross-links on Mechanics Following In Vivo Irradiation in Mice.JBMR plus · 2021Article
- Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesisInternational journal of molecular medicine · 2021Article
- Evidence for Early Stage Anti-Tumor Immunity Elicited by Spatially Fractionated Radiotherapy-Immunotherapy Combinations.Radiation research · 2020Article
- CR6-interacting factor-1 contributes to osteoclastogenesis by inducing receptor activator of nuclear factor κB ligand after radiation.World journal of stem cells · 2020Article
- Therapy-Induced Senescence Drives Bone Loss.Cancer research · 2020Article
- Influence of radiation exposure pattern on the bone injury and osteoclastogenesis in a rat model.International journal of molecular medicine · 2019Article
- Ionizing radiation and bone quality: time-dependent effects.Radiation oncology (London, England) · 2019Article
- Review
- Differences in responses to X-ray exposure between osteoclast and osteoblast cells.Journal of radiation research · 2017Article
- Dosimetry in Micro-computed Tomography: a Review of the Measurement Methods, Impacts, and Characterization of the Quantum GX Imaging System.Molecular imaging and biology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Localized irradiation is a common treatment modality for malignancies in the pelvic-abdominal cavity. We report here on the changes in bone mass and strength in mice 7-14 days after abdominal irradiation. Male C57BL/6 mice of 10-12 weeks of age were given a single-dose (0, 5, 10, 15 or 20 Gy) or fractionated (3 Gy × 2 per day × 7.5 days) X rays to the abdomen and monitored daily for up to 14 days. A decrease in the serum bone formation marker and ex vivo osteoblast differentiation was detected 7 days after a single dose of radiation, with little change in the serum bone resorption marker and ex vivo osteoclast formation. A single dose of radiation elicited a loss of bone mineral density (BMD) within 14 days of irradiation. The BMD loss was up to 4.1% in the whole skeleton, 7.3% in tibia, and 7.7% in the femur. Fractionated abdominal irradiation induced similar extents of BMD loss 10 days after the last fraction: 6.2% in the whole skeleton, 5.1% in tibia, and 13.8% in the femur. The loss of BMD was dependent on radiation dose and was more profound in the trabecula-rich regions of the long bones. Moreover, BMD loss in the total skeleton and the femurs progressed with time. Peak load and stiffness in the mid-shaft tibia from irradiated mice were 11.2-14.2% and 11.5-25.0% lower, respectively, than sham controls tested 7 days after a single-dose abdominal irradiation. Our data demonstrate that abdominal irradiation induces a rapid loss of BMD in the mouse skeleton. These effects are bone type- and region-specific but are independent of radiation fractionation. The radiation-induced abscopal damage to the skeleton is manifested by the deterioration of biomechanical properties of the affected bone.
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