Evidence map›Paper›PMID 21859012›Full record

ArticleMedical physics2011

A theoretical and experimental evaluation of the microangiographic fluoroscope: A high-resolution region-of-interest x-ray imager.

Amit Jain, D R Bednarek, Ciprian Ionita, S Rudin

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Medical physics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. High-Definition Zoom Mode: A High Resolution X-ray Microscope for Neurointerventional Treatment Procedures.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019
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  10. Workflow for the use of a high-resolution image detector in endovascular interventional procedures.Proceedings of SPIE--the International Society for Optical Engineering · 2014
    Article
  11. Design considerations for a new, high resolution Micro-Angiographic Fluoroscope based on a CMOS sensor (MAF-CMOS).Proceedings of SPIE--the International Society for Optical Engineering · 2013
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  12. Theoretical performance analysis for CMOS based high resolution detectors.Proceedings of SPIE--the International Society for Optical Engineering · 2013
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Amit JainToshiba Stroke Research Center, University at Buffalo, State University of New York, Buffalo, New York 14214, USA. ajain6@buffalo.edu
D R Bednarek
Ciprian Ionita
S Rudin
Toshiba (United States) · USUniversity at Buffalo, State University of New York · US

Funding

Micro-Radiographic Imager for Neuroovascular InterventionsR01EB002873 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUDIN, STEPHEN · 2003 to 2015
$5.6M
Solid State X-ray Image Intensifier DevelopmentR01EB008425 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI RUDIN, STEPHEN · 2008 to 2011
$2.6M
NIBIB NIH HHS R01 EB002873NIBIB NIH HHS R01 EB008425
6 · The paper itself

Abstract

purposeThe increasing need for better image quality and high spatial resolution for successful endovascular image-guided interventions (EIGIs) and the inherent limitations of the state-of-the-art detectors provide motivation to develop a detector system tailored to the specific, demanding requirements of neurointerventional applications.

methodA microangiographic fluoroscope (MAF) was developed to serve as a high-resolution, region-of-interest (ROI) x-ray imaging detector in conjunction with large lower-resolution full field-of-view (FOV) state-of-the-art x-ray detectors. The newly developed MAF is an indirect x-ray imaging detector capable of providing real-time images (30 frames per second) with high-resolution, high sensitivity, no lag and low instrumentation noise. It consists of a CCD camera coupled to a Gen 2 dual-stage microchannel plate light image intensifier (LII) through a fiber-optic taper. A 300 microm thick CsI(T1) phosphor serving as the front end is coupled to the LII. The LII is the key component of the MAF and the large variable gain provided by it enables the MAF to operate as a quantum-noise-limited detector for both fluoroscopy and angiography.

resultsThe linear cascade model was used to predict the theoretical performance of the MAF, and the theoretical prediction showed close agreement with experimental findings. Linear system metrics such as MTF and DQE were used to gauge the detector performance up to 10 cycles/mm. The measured zero frequency DQE(0) was 0.55 for an RQA5 spectrum. A total of 21 stages were identified for the whole imaging chain and each stage was characterized individually.

conclusionsThe linear cascade model analysis provides insight into the imaging chain and may be useful for further development of the MAF detector. The preclinical testing of the prototype detector in animal procedures is showing encouraging results and points to the potential for significant impact on EIGIs when used in conjunction with a state-of-art flat panel detector (FPD).

Indexed as

AngiographyComputer-Aided DesignEquipment DesignEquipment Failure AnalysisFluoroscopyMiniaturizationRadiographic Image EnhancementReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID21859012
PMCPMC3143682
OpenAlexW2050964354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.