ArticleHepatology (Baltimore, Md.)2012
Burden of cirrhosis on older Americans and their families: analysis of the health and retirement study.
Article in Hepatology (Baltimore, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 5 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Aminoglycosides, vancomycin, and metronidazole for people with cirrhosis and hepatic encephalopathy.The Cochrane database of systematic reviews · 2026Pooled it
- Branched-chain amino acids for people with cirrhosis and hepatic encephalopathy.The Cochrane database of systematic reviews · 2026Pooled it
- Systematic review: development of a consensus code set to identify cirrhosis in electronic health records.Alimentary pharmacology & therapeutics · 2022Pooled it
- Branched-chain amino acids for people with hepatic encephalopathy.The Cochrane database of systematic reviews · 2017Pooled it
- Systematic review: unmet supportive care needs in people diagnosed with chronic liver disease.BMJ open · 2015Pooled it
- CAREGIVER Randomized Trial of Two Mindfulness Methods to Improve the Burden and Distress of Caring for Persons with Cirrhosis.Digestive diseases and sciences · 2023Trial
- Role of lactulose for prophylaxis against hepatic encephalopathy in cirrhotic patients with upper gastrointestinal bleeding: A randomized trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Trial
- Correction of hyponatraemia improves cognition, quality of life, and brain oedema in cirrhosis.Journal of hepatology · 2015Trial
- Article
- Management of Refractory Hepatic Encephalopathy.Digestive diseases and sciences · 2026Review
- Association between diabetes mellitus and impaired single-leg stance in patients with chronic liver disease: A cross-sectional study.PloS one · 2026Article
- Refractory Post-TIPS Hepatic Encephalopathy Complicated by Small Bowel Obstruction: A Therapeutic Dilemma.Case reports in gastrointestinal medicine · 2026Article
- Testosterone Replacement Reduces Morbidity and Mortality for Most Patients With Cirrhosis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025Article
- The role of rehabilitation across the continuum of liver disease from cirrhosis to transplantation and beyond: A narrative review.PM & R : the journal of injury, function, and rehabilitation · 2025Review
- The Role of Patient-Reported Outcomes in Cirrhosis.The American journal of gastroenterology · 2025Review
- Psychometric hepatic encephalopathy score (PHES) - when, how, why, and why not: a guide for the unfamiliar.Przeglad gastroenterologiczny · 2025Review
- Bisphosphonate effectiveness in patients with cirrhosis: An emulated clinical trial.Alimentary pharmacology & therapeutics · 2024Article
- Racial and Ethnic Disparities in Outcomes After the Development of Ascites: A National Cohort Study.Digestive diseases and sciences · 2024Article
- Comparative Effectiveness and Safety of Apixaban, Rivaroxaban, and Warfarin in Patients With Cirrhosis and Atrial Fibrillation : A Nationwide Cohort Study.Annals of internal medicine · 2024Article
- Advanced liver fibrosis is associated with decreased gait speed in older patients with chronic liver disease.Scientific reports · 2024Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledPrevalence of cirrhosis among older adults is expected to increase; therefore, we studied the health status, functional disability, and need for supportive care in a large national sample of individuals with cirrhosis. A prospective cohort of individuals with cirrhosis was identified within the longitudinal, nationally representative Health and Retirement Study. Cirrhosis cases were identified in linked Medicare data via ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) codes and compared to an age-matched cohort without cirrhosis. Two primary outcome domains were assessed: (1) patients' health status (perceived health status, comorbidities, health care utilization, and functional disability as determined by activities of daily living and instrumental activities of daily living), and (2) informal caregiving (hours of caregiving provided by a primary informal caregiver and associated cost). Adjusted negative binomial regression was used to assess the association between cirrhosis and functional disability. A total of 317 individuals with cirrhosis and 951 age-matched comparators were identified. Relative to the comparison group, individuals with cirrhosis had worse self-reported health status, more comorbidities, and used significantly more health care services (hospitalizations, nursing home stays, physician visits; P < 0.001 for all bivariable comparisons). They also had greater functional disability (P < 0.001 for activities of daily living and instrumental activities of daily living), despite adjustment for covariates such as comorbidities and health care utilization. Individuals with cirrhosis received more than twice the number of informal caregiving hours per week (P < 0.001), at an annual cost of US $4700 per person.
conclusionOlder Americans with cirrhosis have high rates of disability, health care utilization, and need for informal caregiving. Improved care coordination and caregiver support is necessary to optimize management of this frail population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.