Evidence map›Paper›PMID 21858751›Full record

ReviewSeminars in respiratory and critical care medicine2011

Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients.

S Samuel Weigt, Aric L Gregson, Jane C Deng, Joseph P Lynch, John A Belperio

Abstract readReview
In one paragraph

Review in Seminars in respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed.

  1. Respiratory Syncytial Virus Vaccination in Solid Organ Transplant Recipients: Interim Findings From a Phase 3 Trial of mRNA-1345.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Trial
  2. Trial
  3. Trial
  4. Initial High Viral Load Is Associated with Prolonged Shedding of Human Rhinovirus in Allogeneic Hematopoietic Cell Transplant Recipients.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Respiratory Syncytial Virus Infection: An Update.Indian journal of pediatrics · 2023
    Review
  13. Article
  14. Review
  15. Going Viral-RSV as the Neglected Adult Respiratory Virus.Pathogens (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Review
  18. Viruses and atypical bacteria in the respiratory tract of immunocompromised and immunocompetent patients with airway infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  19. COVID-19 in a high-risk dual heart and kidney transplant recipient.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S Samuel WeigtDivision of Pulmonary, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. sweigt@mednet.ucla.edu
Aric L Gregson
Jane C Deng
Joseph P Lynch
John A Belperio

Funding

Immune Mechanisms of AlloinjuryR01HL112990 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BELPERIO, JOHN A · 2012 to 2016
$2.2M
Role of T Regulatory Cells in Preventing Human BOSK23HL102220 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREGSON, ARIC L. · 2011 to 2015
$762k
Role of IRAK-M in sepsis-induced immunosuppressionK08HL081229 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DENG, JANE C · 2005 to 2010
$609k
NHLBI NIH HHS K08 HL081229NHLBI NIH HHS K23 HL102220NHLBI NIH HHS R01 HL112990
6 · The paper itself

Abstract

Respiratory viral infections (RVIs) are common causes of mild illness in immunocompetent children and adults with rare occurrences of significant morbidity or mortality. Complications are more common in the very young, very old, and those with underlying lung diseases. However, RVIs are increasingly recognized as a cause of morbidity and mortality in recipients of hematopoietic stem cell transplants (HSCT) and solid organ transplants (SOTs). Diagnostic techniques for respiratory syncytial virus (RSV), parainfluenza, influenza, and adenovirus have been clinically available for decades, and these infections are known to cause serious disease in transplant recipients. Modern molecular technology has now made it possible to detect other RVIs including human metapneumovirus, coronavirus, and bocavirus, and the role of these viruses in causing serious disease in transplant recipients is still being worked out. This article reviews the current information regarding epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of these infections, as well as the aspects of clinical significance of RVIs unique to HSCT or SOT.

Indexed as

Hematopoietic Stem Cell TransplantationOrgan TransplantationAge FactorsAnimalsHumansImmunocompromised HostLung DiseasesRespiratory Tract InfectionsVirus Diseases

Identifiers

PMID21858751
PMCPMC4209842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.