Trial reportUrological research2012
Role of combined use of potassium citrate and tamsulosin in the management of uric acid distal ureteral calculi.
Trial report in Urological research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Is tamsulosin effective for the passage of symptomatic ureteral stones: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Alpha-blockers as medical expulsive therapy for ureteral stones.The Cochrane database of systematic reviews · 2018Pooled it
- Alpha blockers for treatment of ureteric stones: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Citrate salts for preventing and treating calcium containing kidney stones in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Comparison of efficacy of three commonly used alpha-blockers as medical expulsive therapy for distal ureter stones: A systematic review and network meta-analysis.International braz j urol : official journal of the Brazilian Society of UrologyPooled it
- Tamsulosin versus placebo for medical expulsive therapy in ureteral calculi: a systematic review and meta-analysis of randomized controlled trials.International journal of clinical and experimental pathology · 2026Review
- Construction of an alignment diagram model for predicting calculous obstructive pyonephrosis before PNL.Heliyon · 2024Article
- A New Parameter for Calcium Oxalate Stones: Impact of Linear Calculus Density on Non-Contrast Computed Tomography.Medicina (Kaunas, Lithuania) · 2023Article
- The impact of stenting prior to oral chemolysis of upper urinary tract uric acid stones.International urology and nephrology · 2022Article
- Oral chemolysis is an effective, non-invasive therapy for urinary stones suspected of uric acid content.Urolithiasis · 2020Article
- Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein.Scientific reports · 2015Article
- Acute management of stones: when to treat or not to treat?World journal of urology · 2015Review
- Update on the evaluation of repeated stone formers.Current urology reports · 2013Article
- CUA Guideline: Management of ureteral calculi.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this article, we investigated the effect of the combined use of tamsulosin and potassium citrate (Uralyt-U(®)) for the treatment of uric acid stones in the distal ureter. The study was designed as a prospective, double blind randomized controlled trial. A total of 191 adult patients with radiolucent distal ureteral calculi were recruited. We included patients with solitary stones ≥5 mm with mild or moderate hydronephrosis and a normal contralateral tract. The patients were randomized into four equal groups (the placebo, tamsulosin, Uralyt-U(®), and the combined treatment groups). The patients were treated for a maximum duration of 4 weeks or until stone expulsion. The stone size in all groups ranged from 5 to 11 mm (7.69 ± 1.7 mm). The total expulsion rate of the stones was significantly lower in the control group (26.1%) compared with that of any of the other three groups (68.8, 58.7, and 84.8% respectively) (P < 0.05). Meanwhile, the difference between the Uralyt-U(®) group and the combined treatment group was also statistically significant (P < 0.05). When we studied the patients with stones >8 mm as a separate subgroup to find the effect of the used drugs on the relatively large stones, we detected that the expulsion rate of these stones was significantly higher in the patients who received the combined treatment in comparison with any of the other three groups (P < 0.05). In conclusion, the use of urinary alkalization with tamsulosin can increase the frequency of spontaneous passage of distal ureteral uric acid stones especially those of 8-11 mm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.