ArticleInternational journal of hematology2011
Disappearance of malignant cells by effusion drainage alone in two patients with HHV-8-unrelated HIV-negative primary effusion lymphoma-like lymphoma.
Article in International journal of hematology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Fluid overload-associated large B-cell lymphoma: two case report and review of literature.Frontiers in oncology · 2025Pooled it
- Clinicopathologic and molecular features of primary effusion lymphoma and fluid overload-associated large B-cell lymphoma: A retrospective study.Translational oncology · 2026Article
- Discrepancy of Hans' criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with MYD88 L265P mutation.Journal of clinical and experimental hematopathology : JCEH · 2024Article
- Primary Effusion Lymphoma-like Lymphoma Mimicking Tuberculous Pleural Effusion: Three Case Reports and a Literature Review.Internal medicine (Tokyo, Japan) · 2023Review
- Where has the lymphoma gone? Pericardial effusion adenosine deaminase may play a key role in diagnosing primary effusion lymphoma-like lymphoma: a case report.European heart journal. Case reports · 2023Article
- HHV8 and EBV-negative primary effusion-based lymphoma: A case report of a new provisional entity and review of literature.Clinical case reports · 2023Article
- Development of a human herpesvirus 8-negative effusion-based lymphoma during treatment with dasatinib for chronic myeloid leukemia.Journal of clinical and experimental hematopathology : JCEH · 2023Article
- Fluid overload-associated large B-cell lymphoma with primary biliary cirrhosis: A case report.Frontiers in oncology · 2023Article
- Human herpesvirus 8-negative effusion-based large B-cell lymphoma: a distinct entity with unique clinicopathologic characteristics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- Primary Effusion Lymphoma: A Timely Review on the Association with HIV, HHV8, and EBV.Diagnostics (Basel, Switzerland) · 2022Review
- Primary age-related EBV-associated effusion-based lymphoma successfully treated with rituximab and thoracentesis.Clinical case reports · 2021Article
- Primary HHV-8 (-) Effusion-Based Non-Germinal Center B Cell Diffuse Large B Cell Lymphoma Successfully Treated with Standard Anthracycline-Based Chemoimmunotherapy.Journal of blood medicine · 2021Article
- Human herpesvirus 8-negative effusion-based lymphoma with indolent clinical behavior in an elderly patient: A case report and literature review.Oncology letters · 2020Article
- Primary human herpesvirus 8-negative effusion-based lymphoma: a large B-cell lymphoma with favorable prognosis.Blood advances · 2020Article
- Indolent primary effusion lymphoma-like lymphoma in the pericardium: A case report and review of the literature.Journal of cardiology cases · 2019Article
- EBV-positive PEL-like lymphoma that developed in the course of antisynthetase syndrome treated with tacrolimus.International journal of hematology · 2018Article
- A unique case of primary effusion lymphoma-like lymphoma showing disappearance and recurrence of the body cavity effusion.Journal of general and family medicine · 2017Article
- Primary Effusion Lymphoma in an Elderly HIV-Negative Patient with Hemodialysis: Importance of Evaluation for Pleural Effusion in Patients Receiving Hemodialysis.Case reports in nephrology and urology · 2014Article
- Human herpes virus 8-unrelated primary effusion lymphoma-like lymphoma in a patient with hepatitis B virus-related liver cirrhosis: A case report.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- A Unique Case of Malignant Pleuropericardial Effusion: HHV-8-Unrelated PEL-Like Lymphoma-A Case Report and Review of the Literature.Case reports in oncological medicine · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma usually confined to the body cavities of predominantly immunosuppressed patients infected with human herpes virus-8 (HHV-8). In PEL, malignant cells are usually negative for B-cell markers, such as CD19, CD20, and CD79a, but are positive for activation and plasma cell-related markers, such as CD30, CD38, and CD138. It has been reported that HHV-8-unrelated PEL shows high expression of B-cell markers, which is referred to as PEL-like lymphoma. Here, we report two cases of HHV-8-unrelated HIV-negative PEL-like lymphoma in which malignant cells regressed spontaneously after effusion drainage alone. These cells expressed B-cell markers, such as CD20. No chemotherapy was given to either patient, as they were of an advanced age, and both achieved a complete response by effusion drainage alone. One showed a complete response for 16 months after effusion drainage, and the other has survived for 11 months with a complete response. This suggests that sufficient drainage of serous effusion may induce and maintain a complete response in some patients with HHV-8-unrelated HIV-negative PEL-like lymphoma, which represents an excellent treatment option for elderly patients with this disease.
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