ArticlePloS one2011
GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Structure of the melatonin-related orphan receptor, GPR50.Molecules and cells · 2026Article
- Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the GJournal of pineal research · 2025Article
- ERK-dependent induction of the immediate-early gene Egr1 and the late gene Gpr50 contribute to two distinct phases of PACAP Gs-GPCR signaling for neuritogenesis.Journal of neuroendocrinology · 2022Article
- GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.Cellular and molecular life sciences : CMLS · 2020Article
- GPR50 Distribution in the Mouse Cortex and Hippocampus.Neurochemical research · 2020Article
- GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17.Molecular therapy oncolytics · 2020Article
- Review
- Therapeutic utility of glucocorticoids and antihistamines cotreatment. Rationale and perspectives.Pharmacology research & perspectives · 2019Review
- Significant association between GPR50 hypomethylation and AD in males.Molecular medicine reports · 2019Article
- Melatonin: Countering Chaotic Time Cues.Frontiers in endocrinology · 2019Article
- The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development.Nature communications · 2018Article
- A Review of Melatonin, Its Receptors and Drugs.The Eurasian journal of medicine · 2016Review
- Hunting for the function of orphan GPCRs - beyond the search for the endogenous ligand.British journal of pharmacology · 2015Review
- Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort.Brain and behavior · 2015Article
- Melatonin receptor genes in vertebrates.International journal of molecular sciences · 2013Review
- Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.ACS chemical neuroscience · 2012Article
- Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.Aging and disease · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
GPR50 is an orphan G-protein coupled receptor most closely related to the melatonin receptors. The physiological function of GPR50 remains unclear, although our previous studies implicate the receptor in energy homeostasis. Here, we reveal a role for GPR50 as a signalling partner and modulator of the transcriptional co-activator TIP60. This interaction was identified in a yeast-two-hybrid screen, and confirmed by co-immunoprecipitation and co-localisation of TIP60 and GPR50 in HEK293 cells. Co-expression with TIP60 increased perinuclear localisation of full length GPR50, and resulted in nuclear translocation of the cytoplasmic tail of the receptor, suggesting a functional interaction of the two proteins. We further demonstrate that GPR50 can enhance TIP60-coactiavtion of glucocorticoid receptor (GR) signalling. In line with in vitro results, repression of pituitary Pomc expression, and induction of gluconeogenic genes in liver in response to the GR agonist, dexamethasone was attenuated in Gpr50(-/-) mice. These results identify a novel role for GPR50 in glucocorticoid receptor signalling through interaction with TIP60.
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