ArticlePloS one2011
High burden of non-influenza viruses in influenza-like illness in the early weeks of H1N1v epidemic in France.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Household transmission of 2009 pandemic influenza A (H1N1): a systematic review and meta-analysis.Epidemiology (Cambridge, Mass.) · 2012Pooled it
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- The Role of Viral Interference in Shaping RSV Epidemics Following the 2009 H1N1 Influenza Pandemic.Influenza and other respiratory viruses · 2025Article
- Epidemiology and phylogenetic analysis of respiratory viruses from 2012 to 2015 - A sentinel surveillance report from union territory of Puducherry, India.Clinical epidemiology and global health · 2020Article
- The impact of climate and antigenic evolution on seasonal influenza virus epidemics in Australia.Nature communications · 2020Article
- Epidemiological features and time-series analysis of influenza incidence in urban and rural areas of Shenyang, China, 2010-2018.Epidemiology and infection · 2020Article
- Outbreak of influenza A in a boarding school in South Africa, 2016.The Pan African medical journal · 2019Article
- Shifting patterns of seasonal influenza epidemics.Scientific reports · 2018Article
- Epidemiology of viral respiratory infections in Australian working-age adults (20-64 years): 2010-2013.Epidemiology and infection · 2018Article
- Influenza interaction with cocirculating pathogens and its impact on surveillance, pathogenesis, and epidemic profile: A key role for mathematical modelling.PLoS pathogens · 2018Review
- Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens.Epidemiology and infection · 2017Article
- Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka.The American journal of tropical medicine and hygiene · 2017Article
- Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique.Tropical medicine & international health : TM & IH · 2016Article
- Update on Human Rhinovirus and Coronavirus Infections.Seminars in respiratory and critical care medicine · 2016Review
- Respiratory viruses in young South African children with acute lower respiratory infections and interactions with HIV.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2016Article
- The case for ILI surveillance.Vaccine · 2015Article
- Utility of adding Pneumocystis jirovecii DNA detection in nasopharyngeal aspirates in immunocompromised adult patients with febrile pneumonia.Medical mycology · 2015Article
- Diagnosis of community-acquired acute respiratory illness: From conventional microbiological methods to molecular detection (multiplex).Pathologie-biologie · 2015Article
- Article
- Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality.Epidemiology and infection · 2015Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfluenza-like illness (ILI) may be caused by a variety of pathogens. Clinical observations are of little help to recognise myxovirus infection and implement appropriate prevention measures. The limited use of molecular tools underestimates the role of other common pathogens.
objectivesDuring the early weeks of the 2009-2010 flu pandemic, a clinical and virological survey was conducted in adult and paediatric patients with ILI referred to two French University hospitals in Paris and Tours. Aims were to investigate the different pathogens involved in ILI and describe the associated symptoms.
methodsH1N1v pandemic influenza diagnosis was performed with real time RT-PCR assay. Other viral aetiologies were investigated by the molecular multiplex assay RespiFinder19®. Clinical data were collected prospectively by physicians using a standard questionnaire.
resultsFrom week 35 to 44, endonasal swabs were collected in 413 patients. Overall, 68 samples (16.5%) were positive for H1N1v. In 13 of them, other respiratory pathogens were also detected. Among H1N1v negative samples, 213 (61.9%) were positive for various respiratory agents, 190 in single infections and 23 in mixed infections. The most prevalent viruses in H1N1v negative single infections were rhinovirus (62.6%), followed by parainfluenza viruses (24.2%) and adenovirus (5.3%). 70.6% of H1N1v cases were identified in patients under 40 years and none after 65 years. There was no difference between clinical symptoms observed in patients infected with H1N1v or with other pathogens.
conclusionOur results highlight the high frequency of non-influenza viruses involved in ILI during the pre-epidemic period of a flu alert and the lack of specific clinical signs associated with influenza infections. Rapid diagnostic screening of a large panel of respiratory pathogens may be critical to define and survey the epidemic situation and to provide critical information for patient management.
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