ArticlePloS one2011
Empirical evidence for son-killing X chromosomes and the operation of SA-zygotic drive.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Genetic conflicts: the usual suspects and beyond.The Journal of experimental biology · 2017Review
- Sexually antagonistic zygotic drive: a new form of genetic conflict between the sex chromosomes.Cold Spring Harbor perspectives in biology · 2015Review
- An X-linked sex ratio distorter in Drosophila simulans that kills or incapacitates both noncarrier sperm and sons.G3 (Bethesda, Md.) · 2014Article
- Epigenetics and sex-specific fitness: an experimental test using male-limited evolution in Drosophila melanogaster.PloS one · 2013Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDiploid organisms have two copies of all genes, but only one is carried by each haploid gamete and diploid offspring. This causes a fundamental genetic conflict over transmission rate between alternative alleles. Single genes, or gene clusters, only rarely code for the complex phenotypes needed to give them a transmission advantage (drive phenotype). However, all genes on a male's X and Y chromosomes co-segregate, allowing different sex-linked genes to code for different parts of the drive phenotype. Correspondingly, the well-characterized phenomenon of male gametic drive, occurring during haploid gametogenesis, is especially common on sex chromosomes. The new theory of sexually antagonistic zygotic drive of the sex chromosomes (SA-zygotic drive) extends the logic of gametic drive into the diploid phase of the lifecycle, whenever there is competition among siblings or harmful sib-sib mating. The X and Y are predicted to gain a transmission advantage by harming offspring of the sex that does not carry them.
resultsHere we analyzed a mutant X-chromosome in Drosophila simulans that produced an excess of daughters when transmitted from males. We developed a series of tests to differentiate between gametic and SA-zygotic drive, and provide multiple lines of evidence that SA-zygotic drive is responsible for the sex ratio bias. Driving sires produce about 50% more surviving daughters than sons.
conclusionSex-ratio distortion due to genetic conflict has evolved via gametic drive and maternally transmitted endosymbionts. Our data indicate that sex chromosomes can also drive by harming the non-carrier sex of offspring.
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