ArticlePloS one2011
Preterm delivery disrupts the developmental program of the cerebellum.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 96 citations in OpenAlex.
- Trial
- The Ovine Brain as a Model for Human Neurodevelopment: Immunohistochemical Profiling of Brain Maturation Markers in Preterm Lambs.The Journal of comparative neurology · 2026Article
- Spatiotemporal histogenesis of the developing human cerebellum reveals dynamic layering of Bergmann glia.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cerebellar Development and the Burden of Prematurity.Cerebellum (London, England) · 2025Review
- Impact of Intrauterine Insults on Fetal and Postnatal Cerebellar Development in Humans and Rodents.Cells · 2024Review
- Review
- Review
- Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates.Journal of neuroinflammation · 2024Article
- Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex.Cells · 2023Article
- Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development.eLife · 2023Article
- Neonatal subarachnoid hemorrhage disrupts multiple aspects of cerebellar development.Frontiers in molecular neuroscience · 2023Article
- Cerebellum and neurodevelopmental disorders: RORα is a unifying force.Frontiers in cellular neuroscience · 2023Article
- Association between acute kidney injury and brain injury on term-equivalent age brain magnetic resonance imaging in very preterm infants.Pediatric nephrology (Berlin, Germany) · 2022Article
- Article
- Human Cerebellar Development and Transcriptomics: Implications for Neurodevelopmental Disorders.Annual review of neuroscience · 2022Review
- Review
- Cerebellar development after preterm birth.Frontiers in cell and developmental biology · 2022Review
- Spatial and cell type transcriptional landscape of human cerebellar development.Nature neuroscience · 2021Article
- Article
- Interactions Between Purkinje Cells and Granule Cells Coordinate the Development of Functional Cerebellar Circuits.Neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A rapid growth in human cerebellar development occurs in the third trimester, which is impeded by preterm delivery. The goal of this study was to characterize the impact of preterm delivery on the developmental program of the human cerebellum. Still born infants, which meant that all development up to that age had taken place in-utero, were age paired with preterm delivery infants, who had survived in an ex-utero environment, which meant that their development had also taken place outside the uterus. The two groups were assessed on quantitative measures that included molecular markers of granule neuron, purkinje neuron and bergmann glia differentiation, as well as the expression of the sonic hedgehog signaling pathway, that is important for cerebellar growth. We report that premature birth and development in an ex-utero environment leads to a significant decrease in the thickness and an increase in the packing density of the cells within the external granular layer and the inner granular layer well, as a reduction in the density of bergmann glial fibres. In addition, this also leads to a reduced expression of sonic hedgehog in the purkinje layer. We conclude that the developmental program of the cerebellum is specifically modified by events that follow preterm delivery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.