ArticlePloS one2011
Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Changes in Gut Microbiota and Brain Function in Rats Fed with a copper-overloaded Diet.Biological trace element research · 2026Article
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Rescue of Vasopressin Synthesis in Magnocellular Neurons of the Supraoptic Nucleus Normalises Acute Stress-Induced Adrenocorticotropin Secretion and Unmasks an Effect on Social Behaviour in Male Vasopressin-Deficient Brattleboro Rats.International journal of molecular sciences · 2022Article
- Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion.World journal of gastroenterology · 2020Review
- Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to NJournal of neurochemistry · 2019Article
- Medial prefrontal cortex exacerbates gastric dysfunction of rats upon restraint water‑immersion stress.Molecular medicine reports · 2019Article
- Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer.World journal of gastroenterology · 2019Article
- Altered Neuronal Activity in the Central Nucleus of the Amygdala Induced by Restraint Water-Immersion Stress in Rats.Neuroscience bulletin · 2018Article
- Ventromedial hypothalamic nucleus in regulation of stress-induced gastric mucosal injury in rats.Scientific reports · 2018Article
- Novel transmitters in brain stem vagal neurocircuitry: new players on the pitch.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Arginine Vasopressin Injected into the Dorsal Motor Nucleus of the Vagus Inhibits Gastric Motility in Rats.Gastroenterology research and practice · 2016Article
- Oxytocin in the paraventricular nucleus attenuates incision-induced mechanical allodynia.Experimental and therapeutic medicine · 2015Article
- Differential roles of cyclooxygenase-2-related signaling in regulating hypothalamic neuronal activity under various acute stresses.The Journal of veterinary medical science · 2014Article
- Ionotropic glutamate receptors in hypothalamic paraventricular and supraoptic nuclei mediate vasopressin and oxytocin release in unanesthetized rats.Endocrinology · 2012Article
- Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.Journal of neuroendocrinology · 2012Article
- Naturally occurring variation in vasopressin immunoreactivity is associated with maternal behavior in female Peromyscus mice.Brain, behavior and evolution · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsVasopressin (AVP) and oxytocin (OT) are considered to be related to gastric functions and the regulation of stress response. The present study was to study the role of vasopressinergic and oxytocinergic neurons during the restraint water-immersion stress.
methodsTen male Wistar rats were divided into two groups, control and RWIS for 1h. The brain sections were treated with a dual immunohistochemistry of Fos and oxytocin (OT) or vasopressin (AVP) or OT receptor or AVP 1b receptor (V(1b)R).
results(1) Fos-immunoreactive (Fos-IR) neurons dramatically increased in the hypothalamic paraventricular nucleus (PVN), the supraoptic nucleus (SON), the nucleus of solitary tract (NTS) and motor nucleus of the vagus (DMV) in the RWIS rats; (2) OT-immunoreactive (OT-IR) neurons were mainly observed in the medial magnocellular part of the PVN and the dorsal portion of the SON, while AVP-immunoreactive (AVP-IR) neurons mainly distributed in the magnocellular part of the PVN and the ventral portion of the SON. In the RWIS rats, Fos-IR neurons were identified in 31% of OT-IR neurons and 40% of AVP-IR neurons in the PVN, while in the SON it represented 28%, 53% respectively; (3) V(1b)R-IR and OTR-IR neurons occupied all portions of the NTS and DMV. In the RWIS rats, more than 10% of OTR-IR and V(1b)R-IR neurons were activated in the DMV, while lower ratio in the NTS.
conclusionRWIS activates both oxytocinergic and vasopressinergic neurons in the PVN and SON, which may project to the NTS or DMV mediating the activity of the neurons by OTR and V(1b)R.
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