ArticlePloS one2011
Line tension and stability of domains in cell-adhesion zones mediated by long and short receptor-ligand complexes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Size-dependent protein segregation at membrane interfaces.Nature physics · 2016Article
- The formation of ordered nanoclusters controls cadherin anchoring to actin and cell-cell contact fluidity.The Journal of cell biology · 2015Article
- Membrane adhesion and the formation of heterogeneities: biology, biophysics, and biotechnology.Physical chemistry chemical physics : PCCP · 2015Review
- Physics of cell adhesion: some lessons from cell-mimetic systems.Soft matter · 2014Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Submicron scale domains of membrane-anchored receptors play an important role in cell signaling. Central questions concern the stability of these microdomains, and the mechanisms leading to the domain formation. In immune-cell adhesion zones, microdomains of short receptor-ligand complexes form next to domains of significantly longer receptor-ligand complexes. The length mismatch between the receptor-ligand complexes leads to membrane deformations and has been suggested as a possible cause of the domain formation. The domain formation is a nucleation and growth process that depends on the line tension and free energy of the domains. Using a combination of analytical calculations and Monte Carlo simulations, we derive here general expressions for the line tension between domains of long and short receptor-ligand complexes and for the adhesion free energy of the domains. We argue that the length mismatch of receptor-ligand complexes alone is sufficient to drive the domain formation, and obtain submicron-scale minimum sizes for stable domains that are consistent with the domain sizes observed during immune-cell adhesion.
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Registered trials
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