ArticlePloS one2011
Transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Potential genetic robustness of Prnp and Sprn double knockout mouse embryos towards ShRNA-lentiviral inoculation.Veterinary research · 2022Article
- Article
- Prion Strains and Transmission Barrier Phenomena.Pathogens (Basel, Switzerland) · 2018Review
- Combination analysis of genome-wide association and transcriptome sequencing of residual feed intake in quality chickens.BMC genomics · 2016Article
- Prion protein localizes at the ciliary base during neural and cardiovascular development, and its depletion affects α-tubulin post-translational modifications.Scientific reports · 2015Article
- Article
- Gene expression resulting from PrPC ablation and PrPC overexpression in murine and cellular models.Molecular neurobiology · 2014Review
- To develop with or without the prion protein.Frontiers in cell and developmental biology · 2014Review
- The prion protein family: a view from the placenta.Frontiers in cell and developmental biology · 2014Review
- PrP(C) from stem cells to cancer.Frontiers in cell and developmental biology · 2014Review
- Zebrafish prion protein PrP2 controls collective migration process during lateral line sensory system development.PloS one · 2014Article
- The cellular form of the prion protein is involved in controlling cell cycle dynamics, self-renewal, and the fate of human embryonic stem cell differentiation.Journal of neurochemistry · 2013Article
- Neurotoxicity of prion peptides mimicking the central domain of the cellular prion protein.PloS one · 2013Article
- Prion protein and Shadoo are involved in overlapping embryonic pathways and trophoblastic development.PloS one · 2012Article
- Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.