ArticlePloS one2011
The role of serum biomarkers in predicting fibrosis progression in pediatric and adult hepatitis C virus chronic infection.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Accuracy of noninvasive methods for the diagnosis of liver fibrosis in children with chronic viral hepatitis.BMC gastroenterology · 2022Article
- Circulating Procollagen Type III N-Terminal Peptide and Physical Function in Adults from the Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Modifications of liver stiffness and CXCL4, TGF-β1 and HGF are similar in HCV- and HIV/HCV-infected patients after DAAs.Scientific reports · 2021Article
- Molecular Crosstalk between the Hepatitis C Virus and the Extracellular Matrix in Liver Fibrogenesis and Early Carcinogenesis.Cancers · 2021Review
- Chronic Hepatitis C Pathogenesis: Immune Response in the Liver Microenvironment and Peripheral Compartment.Frontiers in cellular and infection microbiology · 2021Article
- Diagnostic Value of Serum Procollagen III N-Terminal Peptide for Liver Fibrosis in Infantile Cholestasis.Frontiers in pediatrics · 2020Article
- The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia⁻Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats.International journal of molecular sciences · 2019Article
- Hyaluronan content governs tissue stiffness in pancreatic islet inflammation.The Journal of biological chemistry · 2018Article
- A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts.Journal of the American Medical Informatics Association : JAMIA · 2017Article
- Hyaluronic acid concentration in liver diseases.Clinical and experimental medicine · 2016Article
- Article
- Chronic hepatitis C virus infection: Serum biomarkers in predicting liver damage.World journal of gastroenterology · 2016Review
- Hyaluronic acid as a biomarker of fibrosis in chronic liver diseases of different etiologies.Clujul medical (1957) · 2016Review
- Non-invasive diagnosis of liver fibrosis and cirrhosis.World journal of gastroenterology · 2015Review
- Serum hyaluronic acid concentration in Fontan circulation: correlation with hepatic function and portal vein hemodynamics.Pediatric cardiology · 2014Article
- Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia.Hepatitis research and treatment · 2014Article
- Protection effect of kallistatin on carbon tetrachloride-induced liver fibrosis in rats via antioxidative stress.PloS one · 2014Article
- Hyaluronic Acid: from biochemical characteristics to its clinical translation in assessment of liver fibrosis.Hepatitis monthly · 2013Review
- Performance of diagnostic biomarkers in predicting liver fibrosis among hepatitis C virus-infected Egyptian children.Memorias do Instituto Oswaldo Cruz · 2013Article
- A Simple Noninvasive Score Based on Routine Parameters can Predict Liver Cirrhosis in Patients With Chronic Hepatitis C.Hepatitis monthly · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsLiver biopsy represents the gold standard for damage evaluation, but noninvasive serum markers that mirror liver fibrosis progression are actual goals both in adults and especially in children. The aim was to determine specific serum markers that correlate with liver fibrosis progression during chronic HCV infection.
methodsLiver biopsies and concomitant serum samples from 22 pediatric and 22 adult HCV patients were analyzed. Histological parameters were evaluated. On serum TGF-ß1, tissue inhibitor of matrix metalloprotein inhibitor-1 (TIMP-1), hyaluronic acid (HA) and aminoterminal peptide of procollagen type III (PIIINP) were tested.
resultsSignificant fibrosis (F≥2) and advanced fibrosis (F≥3) represented 64% and 20%, respectively in children; while 54% F≥2 and 23% F≥3 in adults. Hyaluronic acid (p = 0.011) and PIIINP (p = 0.016) were related to worse fibrosis stages only in adults, along with TIMP-1 (p = 0.039) just in children; but TGF-ß1 was associated with mild fibrosis (p = 0.022) in adults. The AUROC of TIMP-1 in children to discriminate advanced fibrosis was 0.800 (95%IC 0.598-0.932). In adults, the best AUROCs were that of HA, PIIINP and TGF-ß1 [0.929 (IC95% 0.736-0.994), 0.894 (IC95% 0.689-0.984) and 0.835 (IC95% 0.617-0.957)], respectively. In children, according to the cut off (165.7 ng/mL) value for TIMP-1, biopsies could have been avoided in 72% (18/25). Considering the cut off for HA (109.7 ng/mL), PIIINP (9.1 µg/L), and TGF-ß1 (10,848.3 pg/mL), biopsies could have been avoided in 87% (19/22) of adult patients by using HA and 73% (16/22) using PIIINP or TGF-ß1.
conclusionsIn adults given the diagnostic accuracy of HA, PIIINP, TGF-ß1, their combination may provide a potential useful tool to assess liver fibrosis. This first pediatric study suggests that TIMP-1 is clinically useful for predicting liver fibrosis in HCV patients.
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