ArticlePloS one2011
Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Altered genome induced immune response of iPSCs.Frontiers in immunology · 2026Article
- Nasal mucosa micronuclei as early biomarkers of effect in workers exposed to airborne pollutants: a literature overview.Archives of toxicology · 2025Review
- Generation of Alzheimer's Disease Model Derived from Induced Pluripotent Stem Cells withBiomedicines · 2024Article
- Article
- A Multistep Workflow to Evaluate Newly Generated iPSCs and Their Ability to Generate Different Cell Types.Methods and protocols · 2021Article
- Article
- Human CardioChimeras: Creation of a Novel "Next-Generation" Cardiac Cell.Journal of the American Heart Association · 2020Article
- Expected advances in human fertility treatments and their likely translational consequences.Journal of translational medicine · 2018Review
- Behavioral Variability and Somatic Mosaicism: A Cytogenomic Hypothesis.Current genomics · 2018Review
- Mosaic autosomal aneuploidies are detectable from single-cell RNAseq data.BMC genomics · 2017Article
- Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos.Reproductive biology and endocrinology : RB&E · 2016Article
- Achilles' heel of pluripotent stem cells: genetic, genomic and epigenetic variations during prolonged culture.Cellular and molecular life sciences : CMLS · 2016Review
- Cardiac Stem Cell Hybrids Enhance Myocardial Repair.Circulation research · 2015Article
- Article
- Making it stick: chasing the optimal stem cells for cardiac regeneration.Expert review of cardiovascular therapy · 2014Review
- SNP array profiling of mouse cell lines identifies their strains of origin and reveals cross-contamination and widespread aneuploidy.BMC genomics · 2014Article
- Chromosome instability in mouse embryonic stem cells.Scientific reports · 2014Article
- Genomic instability in pluripotent stem cells: implications for clinical applications.The Journal of biological chemistry · 2014Review
- Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy.Cell death & disease · 2013Article
- EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs.Stem cell research · 2013Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Human pluripotent stem cell (hPSC) lines have been considered to be homogeneously euploid. Here we report that normal hPSC--including induced pluripotent--lines are karyotypic mosaics of euploid cells intermixed with many cells showing non-clonal aneuploidies as identified by chromosome counting, spectral karyotyping (SKY) and fluorescent in situ hybridization (FISH) of interphase/non-mitotic cells. This mosaic aneuploidy resembles that observed in progenitor cells of the developing brain and preimplantation embryos, suggesting that it is a normal, rather than pathological, feature of stem cell lines. The karyotypic heterogeneity generated by mosaic aneuploidy may contribute to the reported functional and phenotypic heterogeneity of hPSCs lines, as well as their therapeutic efficacy and safety following transplantation.
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Registered trials
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