ArticlePloS one2011
Differences in clinical features according to Boryoung and Karp genotypes of Orientia tsutsugamushi.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Global seroprevalence of scrub typhus: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Systematic review of the scrub typhus treatment landscape: Assessing the feasibility of an individual participant-level data (IPD) platform.PLoS neglected tropical diseases · 2021Pooled it
- Comparison of Diagnostic Performance of Commercially Available Serological and Molecular Tests for Detection ofJournal of clinical medicine · 2026Article
- Phylogeographic diversity ofEpidemiology and infection · 2026Article
- Article
- Classifying Eschar Morphologies: Enhancing Early Diagnosis of Scrub Typhus.Journal of Korean medical science · 2025Article
- Genotype Analysis onTropical medicine and infectious disease · 2025Article
- Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.PLoS pathogens · 2025Article
- Dual-Genotype Orientia tsutsugamushi Infections, Hainan Island, China, 2023.Emerging infectious diseases · 2025Article
- Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression.Nature communications · 2024Article
- Comparative analysis of F-18 FDG PET/CT images between scrub typhus and systemic lupus erythematosus.Scientific reports · 2024Article
- Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions.PLoS pathogens · 2024Article
- Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China.PLoS neglected tropical diseases · 2023Article
- A scrub typhus vaccine presents a challenging unmet need.NPJ vaccines · 2023Review
- Clinical, laboratory, and molecular epidemiology of Orientia tsutsugamushi infection from Southwestern India.PloS one · 2023Article
- Representative Genotyping, Recombination and Evolutionary Dynamics Analysis ofFrontiers in cellular and infection microbiology · 2020Article
- Dual Genotype Orientia tsutsugamushi Infection in Patient with Rash and Eschar, Vietnam, 2016.Emerging infectious diseases · 2018Article
- Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India.PLoS neglected tropical diseases · 2018Article
- Molecular Epidemiology of anThe American journal of tropical medicine and hygiene · 2018Article
- Murine models of scrub typhus associated with host control of Orientia tsutsugamushi infection.PLoS neglected tropical diseases · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundScrub typhus is an infectious disease caused by Orientia tsutsugamushi. The differences in virulence of O. tsutsugamushi prototypes in humans are still unknown. We investigated whether there are any differences in the clinical features of the Boryoung and Karp genotypes. METHODOLOGY/PRINCIPAL
findingsPatients infected with O. tsutsugamushi, as Boryoung and Karp clusters, who had visited 6 different hospitals in southwestern Korea were prospectively compared for clinical features, complications, laboratory parameters, and treatment responses. Infected patients in the Boryoung cluster had significantly more generalized weakness, eschars, skin rashes, conjunctival injection, high albumin levels, and greater ESR and fibrinogen levels compared to the Karp cluster. The treatment response to current antibiotics was significantly slower in the Karp cluster as compared to the Boryoung cluster.
conclusionThe frequency of occurrence of eschars and rashes may depend on the genotype of O. tsutsugamushi.
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