ArticlePloS one2011
Associations of IL-4, IL-4R, and IL-13 gene polymorphisms in coal workers' pneumoconiosis in China: a case-control study.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Candidate gene polymorphisms associated with silicosis and coal workers' pneumoconiosis: a systematic review and meta-analysis.BMC pulmonary medicine · 2024Pooled it
- Plasma Cytokine Profiling Reveals Differences between Silicotic Patients with Simple Silicosis and Those with Progressive Massive Fibrosis Caused by Engineered Stone.International journal of molecular sciences · 2023Article
- Association of intronic polymorphisms (rs1549339, rs13402242) and mRNA expression variations in PSMD1 gene in arsenic-exposed workers.Environmental science and pollution research international · 2020Article
- Review
- TNFR/TNF-α signaling pathway regulates apoptosis of alveolar macrophages in coal workers' pneumoconiosis.Oncotarget · 2018Article
- Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers' Pneumoconiosis in a Chinese Population.International journal of environmental research and public health · 2016Article
- Clinical statistics analysis on the characteristics of pneumoconiosis of Chinese miner population.Journal of thoracic disease · 2016Article
- Polymorphisms in interleukin 17A gene and coal workers' pneumoconiosis risk in a Chinese population.BMC pulmonary medicine · 2015Article
- Prevalence Characteristics of Coal Workers' Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China.International journal of environmental research and public health · 2015Article
- Prevalence of pneumoconiosis in Hubei, China from 2008 to 2013.International journal of environmental research and public health · 2014Article
- MUC5B promoter polymorphisms and risk of coal workers' pneumoconiosis in a Chinese population.Molecular biology reports · 2014Article
- Polymorphisms in SPARC and coal workers' pneumoconiosis risk in a Chinese population.PloS one · 2014Article
- Polymorphisms in SELE gene and risk of coal workers' pneumoconiosis in Chinese: a case-control study.PloS one · 2013Article
- Polymorphisms in inflammasome genes and risk of coal workers' pneumoconiosis in a Chinese population.PloS one · 2012Article
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe IL-4, IL-4 receptor (IL4R), and IL-13 genes are crucial immune factors and may influence the course of various diseases. In the present study, we investigated the association between the potential functional polymorphisms in IL-4, IL-4R, and IL-13 and coal workers' pneumoconiosis (CWP) risk in a Chinese population.
methodsSix polymorphisms (C-590T in IL-4, Ile50Val, Ser478Pro, and Gln551Arg in IL-4R, C-1055T and Arg130Gln in IL-13) were genotyped and analyzed in a case-control study of 556 CWP and 541 control subjects.
resultsOur results revealed that the IL-4 CT/CC genotypes were associated with a significantly decreased risk of CWP (odds ratio (OR) = 0.74, 95% confidence interval (CI) = 0.58-0.95), compared with the TT genotype, particularly among subgroups of age <65 years (OR = 0.68, 95%CI = 0.46-0.99) and dust exposure years ≥26 years (OR = 0.69, 95%CI = 0.50-0.94). Moreover, the polymorphism was significantly associated with risk of CWP patients with stage I. In addition, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles (P(trend) = 0.023), and individuals with 11-12 risk alleles had a 47% higher risk of CWP than those with 0-8 risk alleles (OR = 1.47, 95% CI = 1.05-2.05).
conclusionsOur results suggest that the IL-4 C-590T polymorphism is involved in the etiology of CWP and susceptibility to this disease. Larger studies are warranted to validate our findings.
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